Journal article
A 3-way collision tumor of the upper respiratory tract: a composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma
Human pathology, Vol.39(5), pp.781-787
2008
DOI: 10.1016/j.humpath.2007.08.023
PMID: 18284935
Abstract
Composite lymphoma (CL) is composed of 2 or more morphologically and immunophenotypically distinct lymphomas in a single anatomical site. Here we report a unique CL of the upper respiratory tract in an elderly male patient. Morphologically, the lymphoma was composed of 2 distinct and well-demarcated areas consisting of monotonous small to medium-sized lymphocytes and sheets of mature-appearing plasma cells. Immunophenotyping by both flow cytometry and immunohistochemistry revealed that the small to medium-sized lymphocytes were composed of 2 distinct subpopulations sharing a CD5
+/CD19
+/CD20
+/CD22
+/CD23
−/FMC-7(+)/cyclin D1(+) immunophenotype but with different immunoglobulin (Ig) light and heavy chain expression, consistent with 2 immunophenotypically distinct mantle cell lymphomas (MCLs); the plasma cells were composed of CD38(bright +)/CD138
+/IgG
κ-restricted plasma cells, consistent with a plasmacytoma. Fluorescence in situ hybridization showed the t(11;14) translocation present in the lymphocyte region but absent in the plasma cell area. Ig heavy chain gene rearrangement studies on manually dissected populations showed 2 distinct patterns for the MCL and plasmacytoma. To our knowledge, this is the first report of a 3-way CL consisting of 2 immunophenotypically distinct MCLs and a plasmacytoma.
Details
- Title: Subtitle
- A 3-way collision tumor of the upper respiratory tract: a composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma
- Creators
- Huan-You Wang - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9073, USANitin Karandikar - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9073, USADeborah Payne - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9073, USAAtousa Maleki - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9073, USABarbara A Schultz - Department of Otolaryngology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9073, USARobert Collins - Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9073, USARobert W McKenna - Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9073, USA
- Resource Type
- Journal article
- Publication Details
- Human pathology, Vol.39(5), pp.781-787
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.humpath.2007.08.023
- PMID
- 18284935
- ISSN
- 0046-8177
- eISSN
- 1532-8392
- Language
- English
- Date published
- 2008
- Academic Unit
- Pathology
- Record Identifier
- 9984046815102771
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