A 6‐month telephone‐based weight loss intervention in overweight and obese subjects with idiopathic intracranial hypertension

Richard Weil; Betty Kovacs; Neil Miller; Michael P McDermott; Michael Wall; Mark Kupersmith; F. Xavier Pi‐Sunyer; NORDIC Idiopathic Intracranial Hypertension Study Group

doi:10.1002/osp4.34

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A 6‐month telephone‐based weight loss intervention in overweight and obese subjects with idiopathic intracranial hypertension

Journal article

Open access

Peer reviewed

A 6‐month telephone‐based weight loss intervention in overweight and obese subjects with idiopathic intracranial hypertension

Richard Weil, Betty Kovacs, Neil Miller, Michael P McDermott, Michael Wall, Mark Kupersmith, F. Xavier Pi‐Sunyer and NORDIC Idiopathic Intracranial Hypertension Study Group

Obesity Science & Practice, Vol.2(2), pp.95-103

06/2016

DOI: 10.1002/osp4.34

PMCID: PMC5523694

PMID: 29071096

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Abstract

Summary Objectives The purpose of this paper is to measure the change in body weight after a 6‐month telephone‐based weight loss intervention in overweight and obese subjects with idiopathic intracranial hypertension (IIH) and mild visual loss randomized to receive either acetazolamide or placebo. Methods One hundred sixty‐five subjects with IIH, aged 29.1 ± 7.5 (mean ± SD) and BMI 39.9 + 8.3 kg/m2, enrolled at 38 academic and private practice sites in North America, participated in this trial. This was a randomized, double‐masked, placebo‐controlled trial of acetazolamide in subjects with IIH and mild visual loss. All participants received a reduced‐sodium, weight‐reduction diet and a 6‐month telephone‐based weight loss intervention. Six‐month changes from baseline in body weight, perimetric mean deviation as assessed by automated perimetry and quality of life using the National Eye Institute Visual Function Questionnaire 25 and the 36‐item Short Form Health Survey were measured. Results Mean percent weight change at 6 months was −5.9% ± 6.7% of initial body weight overall, −3.5% ± 5.9% in the placebo group and −7.8% ± 6.8% in the acetazolamide group. Weight change was not associated with changes in either mean deviation or quality of life scores. Conclusion Patients with IIH and mild visual loss assigned to either acetazolamide or placebo, all of whom received a 6‐month telephone‐based weight loss intervention, lost an average of 5.9% of initial body weight, consistent with NHLBI guidelines of 5% to 10% of body weight loss for clinically significant health benefit.

telephone‐based weight loss programme

weight loss

Adults

clinical research

idiopathic intracranial hypertension

Details

Title: Subtitle: A 6‐month telephone‐based weight loss intervention in overweight and obese subjects with idiopathic intracranial hypertension
Creators: Richard Weil - Mt Sinai St Luke's Hospital
Betty Kovacs - Mt Sinai St Luke's Hospital
Neil Miller - Johns Hopkins University School of Medicine
Michael P McDermott - University of Rochester Medical Center
Michael Wall - University of Iowa Carver College of Medicine
Mark Kupersmith - Mt. Sinai Roosevelt Hospital and New York Eye and Ear Infirmary
F. Xavier Pi‐Sunyer - Columbia University Medical Center
NORDIC Idiopathic Intracranial Hypertension Study Group
Resource Type: Journal article
Publication Details: Obesity Science & Practice, Vol.2(2), pp.95-103
DOI: 10.1002/osp4.34
PMID: 29071096
PMCID: PMC5523694
NLM abbreviation: Obes Sci Pract
ISSN: 2055-2238
eISSN: 2055-2238
Number of pages: 9
Grant note: NIH (2P30DK0126687; 3U10EY017281‐01A1S2; U10 EY017281) National Eye Institute (1U10EY017281‐01A1; DCBC 1U10EY017387‐01A1; 3U10EY017281‐01A1S1; DCBC 1U10EY017387‐01A1S1)
Language: English
Date published: 06/2016
Academic Unit: Neurology; Ophthalmology and Visual Sciences
Record Identifier: 9983979983002771

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