Journal article
A Basal Forebrain Site Coordinates the Modulation of Endocrine and Behavioral Stress Responses via Divergent Neural Pathways
The Journal of neuroscience, Vol.36(33), pp.8687-8699
08/17/2016
DOI: 10.1523/JNEUROSCI.1185-16.2016
PMCID: PMC4987438
PMID: 27535914
Abstract
The bed nuclei of the stria terminalis (BST) are critically important for integrating stress-related signals between the limbic forebrain and hypothalamo-pituitary-adrenal (HPA) effector neurons in the paraventricular hypothalamus (PVH). Nevertheless, the circuitry underlying BST control over the stress axis and its role in depression-related behaviors has remained obscure. Utilizing optogenetic approaches in rats, we have identified a novel role for the anteroventral subdivision of BST in the coordinated inhibition of both HPA output and passive coping behaviors during acute inescapable (tail suspension, TS) stress. Follow-up experiments probed axonal pathways emanating from the anteroventral BST which accounted for separable endocrine and behavioral functions subserved by this cell group. The PVH and ventrolateral periaqueductal gray were recipients of GABAergic outputs from the anteroventral BST that were necessary to restrain stress-induced HPA activation and passive coping behavior, respectively, during TS and forced swim tests. In contrast to other BST subdivisions implicated in anxiety-like responses, these results direct attention to the anteroventral BST as a nodal point in a stress-modulatory network for coordinating neuroendocrine and behavioral coping responses, wherein impairment could account for core features of stress-related mood disorders.
Dysregulation of the neural pathways modulating stress-adaptive behaviors is implicated in stress-related psychiatric illness. While aversive situations activate a network of limbic forebrain regions thought to mediate such changes, little is known about how this information is integrated to orchestrate complex stress responses. Here we identify novel roles for the anteroventral bed nuclei of the stria terminalis in inhibiting both stress hormone output and passive coping behavior via divergent projections to regions of the hypothalamus and midbrain. Inhibition of these projections produced features observed with rodent models of depression, namely stress hormone hypersecretion and increased passive coping behavior, suggesting that dysfunction in these networks may contribute to expression of pathological changes in stress-related disorders.
Details
- Title: Subtitle
- A Basal Forebrain Site Coordinates the Modulation of Endocrine and Behavioral Stress Responses via Divergent Neural Pathways
- Creators
- Shane B Johnson - Interdisciplinary Neuroscience ProgramEric B Emmons - Interdisciplinary Neuroscience ProgramRachel M Anderson - Department of Psychological and Brain Sciences, andRyan M Glanz - Department of Psychological and Brain Sciences, andSara A Romig-Martin - Department of Psychological and Brain Sciences, andNandakumar S Narayanan - Interdisciplinary Neuroscience Program, Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242Ryan T LaLumiere - Interdisciplinary Neuroscience Program, Department of Psychological and Brain Sciences, andJason J Radley - Interdisciplinary Neuroscience Program, Department of Psychological and Brain Sciences, and Jason-radley@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.36(33), pp.8687-8699
- Publisher
- United States
- DOI
- 10.1523/JNEUROSCI.1185-16.2016
- PMID
- 27535914
- PMCID
- PMC4987438
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Grant note
- R01 MH104384 / NIMH NIH HHS R01 MH095972 / NIMH NIH HHS R01 NS089470 / NINDS NIH HHS R56 MH095972 / NIMH NIH HHS R01 DA034684 / NIDA NIH HHS
- Language
- English
- Date published
- 08/17/2016
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984020651902771
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