Journal article
A Biobehavioral Perspective of Tumor Biology
Discovery medicine, Vol.5(30), pp.520-526
12/2005
PMCID: PMC3144932
PMID: 20704834
Abstract
The perspective that cancer may be causally linked to stress has a long history. In 200 AD, Galen proposed that melancholic women were more susceptible to cancer than women who were sanguine. Rigorous examinations of related observations have lagged over the ensuing centuries. More recently, epidemiologic studies have shown that psychologic and social characteristics (e.g., chronic stress and negative life events, social isolation and support, socioeconomic burden, and emotional processes) might be associated with differential cancer incidence, progression, and mortality. The biologic mechanisms (e.g., signaling pathways) that may account for such observations are being discovered through the convergence of relevant molecular, cellular, and clinical data. In this article, we review the clinical and experimental evidence regarding the effects of stress on tumor development, growth, and progression. Within this context, we define "stress" as an external event ("stressor") or perception of such events that engender psychologic and physiologic changes ("stress responses") designed to approach, avoid, or defend against the external event.
Details
- Title: Subtitle
- A Biobehavioral Perspective of Tumor Biology
- Creators
- Paige Green McDonald - Basic and Biobehavioral Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USAMichael H Antoni - Departments of Psychology and Psychiatry and Behavioral Sciences, and the Sylvester Comprehensive Cancer Center, University of Miami, Coral Gables, FL 33124, USASusan K Lutgendorf - Departments of Psychology and Obstetrics and Gynecology and the Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USASteven W Cole - Division of Hematology-Oncology, University of California School of Medicine, Los Angeles, CA 90095, USAFirdaus S Dhabhar - Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USASandra E Sephton - Department of Psychological and Brain Sciences, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USAMichael Stefanek - American Cancer Society, Atlanta, GA 30329, USAAnil K Sood - Departments of Gynecologic Oncology and Cancer Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77230, USA
- Resource Type
- Journal article
- Publication Details
- Discovery medicine, Vol.5(30), pp.520-526
- PMID
- 20704834
- PMCID
- PMC3144932
- NLM abbreviation
- Discov Med
- ISSN
- 1539-6509
- eISSN
- 1944-7930
- Grant note
- R01 CA110793-01 || CA / National Cancer Institute : NCI
- Language
- English
- Date published
- 12/2005
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984065772702771
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