Journal article
A Brief Critique of the TATES Procedure
Behavior genetics, Vol.48(2), pp.155-167
03/2018
DOI: 10.1007/s10519-018-9890-6
PMCID: PMC6028780
PMID: 29468442
Abstract
The Trait-based test that uses the Extended Simes procedure (TATES) was developed as a method for conducting multivariate GWAS for correlated phenotypes whose underlying genetic architecture is complex. In this paper, we provide a brief methodological critique of the TATES method using simulated examples and a mathematical proof. Our simulated examples using correlated phenotypes show that the Type I error rate is higher than expected, and that more TATES p values fall outside of the confidence interval relative to expectation. Thus the method may result in systematic inflation when used with correlated phenotypes. In a mathematical proof we further demonstrate that the distribution of TATES p values deviates from expectation in a manner indicative of inflation. Our findings indicate the need for caution when using TATES for multivariate GWAS of correlated phenotypes.
Details
- Title: Subtitle
- A Brief Critique of the TATES Procedure
- Creators
- Fazil Aliev - grid.440448.8 Department of Actuarial and Risk Management Karabuk University Karabuk TurkeyJessica Salvatore - 0000 0004 0458 8737 grid.224260.0 Virginia Institute for Psychiatric and Behavioral Genetics Virginia Commonwealth University Richmond VA USAArpana Agrawal - 0000 0001 2355 7002 grid.4367.6 Department of Psychiatry Washington University School of Medicine St. Louis MO USALaura Almasy - 0000 0001 2215 0219 grid.250889.e Department of Genetics Texas Biomedical Research Institute San Antonio TX USAGrace Chan - 0000000419370394 grid.208078.5 Department of Psychiatry University of Connecticut Health Center Farmington CT USAHoward Edenberg - 0000 0001 2287 3919 grid.257413.6 Department of Biochemistry and Molecular Biology Indiana University School of Medicine Indianapolis IN USAVictor Hesselbrock - 0000000419370394 grid.208078.5 Department of Psychiatry University of Connecticut Health Center Farmington CT USASamuel Kuperman - 0000 0004 0434 9816 grid.412584.e Division of Child Psychiatry University of Iowa Hospitals Iowa City IA USAJacquelyn Meyers - 0000 0001 0693 2202 grid.262863.b Department of Psychiatry State University of New York Downstate Medical Center New York NY USADanielle Dick - 0000 0004 0458 8737 grid.224260.0 Department of Human & Molecular Genetics Virginia Commonwealth University Richmond VA USA
- Resource Type
- Journal article
- Publication Details
- Behavior genetics, Vol.48(2), pp.155-167
- DOI
- 10.1007/s10519-018-9890-6
- PMID
- 29468442
- PMCID
- PMC6028780
- NLM abbreviation
- Behav Genet
- ISSN
- 0001-8244
- eISSN
- 1573-3297
- Publisher
- Springer US; New York
- Grant note
- 114C117 / TUBITAK DA32573 / National Institute on Drug Abuse (http://dx.doi.org/10.13039/100000026) P30 CA91842 / National Cancer Institute (http://dx.doi.org/10.13039/100000054) U01HG004438 / National Institutes of Health (http://dx.doi.org/10.13039/100000002) U10AA008401; F32AA022269; K01AA024152; K02AA018755 / National Institute on Alcohol Abuse and Alcoholism (http://dx.doi.org/10.13039/100000027) HHSN268200782096C / National Institutes of Health (http://dx.doi.org/10.13039/100000002) UL1RR024992 / National Center for Research Resources (http://dx.doi.org/10.13039/100000097)
- Language
- English
- Date published
- 03/2018
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984004075702771
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