Journal article
A C-fiber reflex inhibition induced by electroacupuncture with different intensities applied at homotopic and heterotopic acupoints in rats selectively destructive effects on myelinated and unmyelinated afferent fibers
Brain research, Vol.1011(2), pp.228-237
2004
DOI: 10.1016/j.brainres.2004.03.034
PMID: 15157809
Abstract
The aims of this study were to explore the C-fiber reflex inhibition induced by electroacupuncture with different intensities applied at homotopic or heterotopic acupoints, and to determine the influence selectively destroyed myelinated and unmyelinated afferent fibers on the C-fiber reflex inhibition. In the ipsilateral local acupoint, the general behavior of the C-fiber reflex can be depressed by electroacupuncture below the threshold of Aδ-fiber activation. Electroacupuncture stimulation within the intensity of Aδ-fiber activation applied to the ipsilateral limb pretreated with cobra venom did not elicit inhibition of C-fiber reflex in rats with demyelinated sciatic nerve. However, heterotopic electroacupuncture below the threshold of Aδ-fiber activation was totally ineffective. In contralateral heterotopic acupoints, the C-fiber reflex can be depressed only by electroacupuncture with stimulating intensities exceeding thresholds of Aδ and C-fiber activation. Electroacupuncture stimuli applied to capsaicin-pretreated limb in the intensities of threshold of Aδ-fiber and treble thresholds of C-fiber activation produced only a little inhibition of C-fiber reflex. Inhibitory intensity was roughly similar to that induced by the stimulation with intensity for the activation of Aδ-fiber in normal animal. In the spinalized animals transections at T
6–T
7 segments, regardless of intensities, the homotopic electroacupuncture stimulation only induced moderate depression of C-fiber reflex similar to that of Aδ-fiber activation; whereas, no matter what intensities of application, the inhibitory effects of C-fiber reflex disappeared totally by using heterotopic noxious electroacupuncture in these animals.
Details
- Title: Subtitle
- A C-fiber reflex inhibition induced by electroacupuncture with different intensities applied at homotopic and heterotopic acupoints in rats selectively destructive effects on myelinated and unmyelinated afferent fibers
- Creators
- Bing Zhu - Institute of Acupuncture, China Academy of Traditional Chinese Medicine, 16 Nanxiaojie of Dongzhimen, Beijing 100700, ChinaWei-Dong Xu - Institute of Acupuncture, China Academy of Traditional Chinese Medicine, 16 Nanxiaojie of Dongzhimen, Beijing 100700, ChinaPei-Jing Rong - Institute of Acupuncture, China Academy of Traditional Chinese Medicine, 16 Nanxiaojie of Dongzhimen, Beijing 100700, ChinaHui Ben - Institute of Acupuncture, China Academy of Traditional Chinese Medicine, 16 Nanxiaojie of Dongzhimen, Beijing 100700, ChinaXin-Yan Gao - Institute of Acupuncture, China Academy of Traditional Chinese Medicine, 16 Nanxiaojie of Dongzhimen, Beijing 100700, China
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.1011(2), pp.228-237
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.brainres.2004.03.034
- PMID
- 15157809
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 2004
- Academic Unit
- Iowa Neuroscience Institute; Anesthesia
- Record Identifier
- 9984006349202771
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