Journal article
A Candidate Gene Study of Tardive Dyskinesia in the CATIE Schizophrenia Trial
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.153B(1), pp.336-340
01/01/2010
DOI: 10.1002/ajmg.b.30981
PMCID: PMC3894657
PMID: 19475583
Abstract
Tardive dyskinesia (TD) is a movement disorder characterized by involuntary oro-facial, limb, and truncal movements. As a genetic basis for inter-individual variation is assumed, there have been a sizeable number of candidate gene studies. All subjects met diagnostic criteria for schizophrenia and were randomized to receive antipsychotic medications as participants in the Clinical Antipsychotic Trials of Intervention Effectiveness project (CATIE). TD was assessed via the Abnormal Involuntary Movement Scale at regular intervals. Probable TD was defined as meeting Schooler-Kane criteria at any scheduled CATIE visit (207/710 subjects, 29.2%). A total of 128 candidate genes were studied in 710 subjects-2,580 SNPs in 118 candidate genes selected from the literature (e.g., dopamine, serotonin, glutamate, and GABA pathways) and composite genotypes for 10 drug-metabolizing enzymes. No single marker or haplotype association reached statistical significance after adjustment for multiple comparisons. Thus, we found no support for either novel or prior associations from the literature. (C) 2009 Wiley-Liss, Inc.
Details
- Title: Subtitle
- A Candidate Gene Study of Tardive Dyskinesia in the CATIE Schizophrenia Trial
- Creators
- Huei-Ting Tsai - University of North Carolina at Chapel HillStanley N. Caroff - University of PennsylvaniaDel D. Miller - University of IowaJoseph McEvoy - Duke UniversityJeffrey A. Lieberman - Columbia UniversityKari E. North - University of North Carolina at Chapel HillT. Scott Stroup - University of North Carolina at Chapel HillPatrick F. Sullivan - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.153B(1), pp.336-340
- Publisher
- Wiley
- DOI
- 10.1002/ajmg.b.30981
- PMID
- 19475583
- PMCID
- PMC3894657
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Number of pages
- 5
- Grant note
- P30ES010126 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01 MH90001 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01MH074027 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Language
- English
- Date published
- 01/01/2010
- Academic Unit
- Psychiatry
- Record Identifier
- 9984280866802771
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