A Case of Complete Functional Myocardial Regeneration in a Human Neonate

Jyoti Gur; Rajiv Devanagondi; Rebecca Pratt; Frank Smith; Jason Mandell; Susan Martin; George A. Porter

doi:10.1016/j.jaccas.2025.103622

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A Case of Complete Functional Myocardial Regeneration in a Human Neonate

Journal article

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Peer reviewed

A Case of Complete Functional Myocardial Regeneration in a Human Neonate

Jyoti Gur, Rajiv Devanagondi, Rebecca Pratt, Frank Smith, Jason Mandell, Susan Martin and George A. Porter

JACC. Case reports, Vol.30(14), 103622

06/11/2025

DOI: 10.1016/j.jaccas.2025.103622

PMCID: PMC12237733

PMID: 40514120

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Abstract

Background: Multiple studies demonstrate the cardiac regenerative capacity in neonatal mice in the first week of life. Although a similar regenerative window in the human neonatal hearts has not been defined clearly, existing evidence supports the concept of human neonatal cardiac regeneration. Case Summary: A neonate with a complex form of cyanotic tetralogy of Fallot demonstrated complete recovery of left ventricular function after an acute cardiac injury suffered on day of life 8. Discussion: This case report adds to limited but intriguing observations that human neonatal hearts may possess the regenerative capacity observed in animal models and that that capacity may be prolonged by hypoxemia. Take-Home Messages: A human neonatal heart has shown complete functional recovery after an ischemic injury. Hypoxemia may have extended the regenerative window of the human neonatal myocardium.

Congenital Heart Disease

Ischemia

cardiac regeneration

hypoxemia

Details

Title: Subtitle: A Case of Complete Functional Myocardial Regeneration in a Human Neonate
Creators: Jyoti Gur - University of Rochester
Rajiv Devanagondi - University of Rochester
Rebecca Pratt - University at Buffalo, State University of New York
Frank Smith - SUNY Upstate Medical University
Jason Mandell - University of Rochester
Susan Martin - University of Rochester
George A. Porter - University of Rochester
Resource Type: Journal article
Publication Details: JACC. Case reports, Vol.30(14), 103622
DOI: 10.1016/j.jaccas.2025.103622
PMID: 40514120
PMCID: PMC12237733
NLM abbreviation: JACC Case Rep
ISSN: 2666-0849
eISSN: 2666-0849
Language: English
Date published: 06/11/2025
Academic Unit: Cardiology; Stead Family Department of Pediatrics
Record Identifier: 9984828337902771

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