Journal article
A Cholinergic Receptor Gene (CHRM2) Affects Event-related Oscillations
Behavior genetics, Vol.36(5), pp.627-639
09/2006
DOI: 10.1007/s10519-006-9075-6
PMID: 16823639
Abstract
We report genetic linkage and association findings which implicate the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) in the modulation of a scalp-recorded electrophysiological phenotype. The P3 (P300) response was evoked using a three-stimulus visual oddball paradigm and a phenotype that relates to the energy in the theta band (4–5 Hz) was analyzed. Studies have shown that similar electrophysiological measures represent cognitive correlates of attention, working memory, and response selection; a role has been suggested for the ascending cholinergic pathway in the same functions. The results of our genetic association tests, combined with knowledge regarding the presence of presynaptic cholinergic M2 autoreceptors in the basal forebrain, indicate that the cognitive processes required by the experiment may in part be mediated by inhibitory neural networks. These findings underscore the utility of electrophysiology and neurogenetics in the understanding of cognitive function and the study of brain-related disorders.
Details
- Title: Subtitle
- A Cholinergic Receptor Gene (CHRM2) Affects Event-related Oscillations
- Creators
- Kevin Jones - Department of Psychiatry SUNY Health Science Center 450 Clarkson Avenue Box 1203 Brooklyn NY 11203 USABernice Porjesz - Department of Psychiatry SUNY Health Science Center 450 Clarkson Avenue Box 1203 Brooklyn NY 11203 USALaura Almasy - Southwest Foundation for Biomedical Research San Antonio TX USALaura Bierut - Washington University School of Medicine St. Louis MO USADanielle Dick - Washington University School of Medicine St. Louis MO USAAlison Goate - Washington University School of Medicine St. Louis MO USAAnthony Hinrichs - Washington University School of Medicine St. Louis MO USAJohn Rice - Washington University School of Medicine St. Louis MO USAJen Wang - Washington University School of Medicine St. Louis MO USALance Bauer - University of Connecticut Farmington CT USARaymond Crowe - University of Iowa, Psychiatry Research Iowa City IA USATatiana Foroud - Indiana University School of Medicine Indianapolis IN USAVictor Hesselbrock - University of Connecticut Farmington CT USASamuel Kuperman - University of Iowa, Psychiatry Research Iowa City IA USAJohn Nurnberger Jr - Indiana University School of Medicine Indianapolis IN USASean O’Connor - Indiana University School of Medicine Indianapolis IN USAJohn Rohrbaugh - Washington University School of Medicine St. Louis MO USAMarc Schuckit - University of California San Diego CA USAJay Tischfield - Rutgers University Piscataway NJ USAHoward Edenberg - Indiana University School of Medicine Indianapolis IN USAHenri Begleiter - Department of Psychiatry SUNY Health Science Center 450 Clarkson Avenue Box 1203 Brooklyn NY 11203 USA
- Resource Type
- Journal article
- Publication Details
- Behavior genetics, Vol.36(5), pp.627-639
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- DOI
- 10.1007/s10519-006-9075-6
- PMID
- 16823639
- ISSN
- 0001-8244
- eISSN
- 1573-3297
- Language
- English
- Date published
- 09/2006
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003455202771
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