Journal article
A Clinical Comparison between Intrathecal and Intravenous Infusion of Magnesium Sulphate as an Adjuvant to Hyperbaric 0.5% Bupivacaine in Spinal Anaesthesia for Elective Infraumbilical Surgeries
Annals of international medical and dental research, Vol.3(2), pp.23-29
02/19/2017
Abstract
Background: This study was conducted to compare the effects of intrathecal magnesium and intravenous infusion of magnesium sulphate as adjuvants to bupivacaine for intrathecal anaesthesia. Methods: A prospective, randomized, double-blinded, placebo controlled study was planned in 90 patients of physical status ASA I and II, aged between 18 to 55 years, scheduled to undergo elective surgery below the level of umbilicus. Patients were randomly assigned into three equal groups A,B & C (n=30 per group) according to a computer generated list. Group A received 15mg of 0.5% bupivacaine + 0.15ml of 50% magnesium sulphate (75mg) + 0.35ml of sterile water, Group B received 15mg of 0.5% bupivacaine + 0.5ml sterile water + a bolus dose of magnesium sulphate 50mg/kg in 100ml saline over 10 minutes followed by a continuous infusion of 15mg/kg/hr until the end of the surgery and group C received 15mg of 0.5% bupivacaine + 0.5ml sterile water (Placebo). Preoperative serum magnesium levels were checked, and repeated at 6h and 24hrs postoperatively. Results: Time to 2 segment regression of sensory block, duration of spinal anaesthesia as well as duration of effective analgesia were significantly prolonged in intrathecal as well as intravenous magnesium as compared to placebo. Intrathecal or intravenous magnesium were not associated with significant side effects.Conclusion: Co-administration of intravenous or intrathecal Mg given to patients undergoing spinal anesthesia for elective infraumbilical surgeries could improve pain control for the first 24 h after surgery. Intrathecal as well as intravenous magnesium sulphate significantly prolonged the time for the first analgesic request, thus substantiating their use in postoperative analgesia.
Details
- Title: Subtitle
- A Clinical Comparison between Intrathecal and Intravenous Infusion of Magnesium Sulphate as an Adjuvant to Hyperbaric 0.5% Bupivacaine in Spinal Anaesthesia for Elective Infraumbilical Surgeries
- Creators
- Hari Krishna DalaiShree NandaSiddharth Chavali
- Resource Type
- Journal article
- Publication Details
- Annals of international medical and dental research, Vol.3(2), pp.23-29
- ISSN
- 2395-2814
- eISSN
- 2395-2822
- Language
- English
- Date published
- 02/19/2017
- Academic Unit
- Anesthesia
- Record Identifier
- 9984771642302771
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