A Comparative Study of Central Corneal Epithelial, Stromal, and Total Thickness in Males With and Without Primary Open-Angle Glaucoma

Hatim Batawi; Ivonne Valentina Lollett; Cima Maliakal; Sarah R Wellik; Michael G Anderson; William Feuer; Carol L Karp; Anat Galor

doi:10.1097/ICO.0000000000001575

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A Comparative Study of Central Corneal Epithelial, Stromal, and Total Thickness in Males With and Without Primary Open-Angle Glaucoma

Journal article

Peer reviewed

A Comparative Study of Central Corneal Epithelial, Stromal, and Total Thickness in Males With and Without Primary Open-Angle Glaucoma

Hatim Batawi, Ivonne Valentina Lollett, Cima Maliakal, Sarah R Wellik, Michael G Anderson, William Feuer, Carol L Karp and Anat Galor

Cornea, Vol.37(6), pp.712-719

06/2018

DOI: 10.1097/ICO.0000000000001575

PMCID: PMC5938118

PMID: 29553989

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Abstract

To compare the central corneal epithelial thickness (CET), stromal thickness (CST), and total thickness (CCT) in males with and without primary open-angle glaucoma and to determine the factors associated with corneal thickness. A case-control study was conducted to evaluate 116 male patients at the Miami Veterans Affair Medical Center. Subjects with available anterior segment optical coherence tomography images (Cirrus HD-OCT, Carl Zeiss Meditec Inc, Dublin, CA) were retrospectively classified into 2 groups by glaucoma status. CET, CST, and CCT measurements between the groups were compared. Associations between thickness and other variables of interest were also evaluated. The 2 groups were similar with respect to race and ethnicity. Mean age of patients in the glaucoma group (70.3 ± 8.9) was higher than in the nonglaucoma group (66.0 ± 11.7), P < 0.03. Individuals who self-identified as black had lower CST (447.8 ± 29.0 μm) and CCT (503.0 ± 30.5 μm) compared with whites (CST: 470.0 ± 31.7 μm; CCT: 525.1 ± 32.4 μm), P = 0.0001 and P = 0.0002, respectively. In a similar manner, individuals with glaucoma had lower CST (453.4 ± 32.5 μm) and CCT (507.3 ± 33.8 μm) than that of those without glaucoma (CST: 465.2 ± 31.2 μm; CCT: 521.5 ± 31.5 μm), P = 0.05 and P = 0.02, respectively. CET, CST, and CCT were negatively correlated with the number of antiglaucoma medications (r = -0.2, r = -0.22, and r = -0.25, respectively), P = 0.05 for all. Individuals with glaucoma have lower CST and CCT measurements compared with individuals without glaucoma. An increased number of glaucoma medications were associated with lower thickness measurements.

Adult

Aged

Aged, 80 and over

Antihypertensive Agents - therapeutic use

Case-Control Studies

Cornea - pathology

Corneal Stroma - pathology

Epithelium, Corneal - pathology

Glaucoma, Open-Angle - pathology

Humans

Male

Middle Aged

Regression Analysis

Risk Factors

Details

Title: Subtitle: A Comparative Study of Central Corneal Epithelial, Stromal, and Total Thickness in Males With and Without Primary Open-Angle Glaucoma
Creators: Hatim Batawi - Department of Ophthalmology, King Abdul Aziz University, Jeddah, Saudi Arabia
Ivonne Valentina Lollett - Bascom Palmer Eye Institute, University of Miami, Miami, FL
Cima Maliakal - University of Miami, Miller School of Medicine, Miami, FL
Sarah R Wellik - Bascom Palmer Eye Institute, University of Miami, Miami, FL
Michael G Anderson - Departments of Ophthalmology and Visual Science and Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA
William Feuer - Bascom Palmer Eye Institute, University of Miami, Miami, FL
Carol L Karp - Bascom Palmer Eye Institute, University of Miami, Miami, FL
Anat Galor - Bascom Palmer Eye Institute, University of Miami, Miami, FL
Resource Type: Journal article
Publication Details: Cornea, Vol.37(6), pp.712-719
DOI: 10.1097/ICO.0000000000001575
PMID: 29553989
PMCID: PMC5938118
NLM abbreviation: Cornea
ISSN: 0277-3740
eISSN: 1536-4798
Grant note: R01 EY026174 / NEI NIH HHS I01 RX001481 / RRD VA P30 EY014801 / NEI NIH HHS I01 CX001089 / CSRD VA R01 EY017673 / NEI NIH HHS
Language: English
Date published: 06/2018
Academic Unit: Molecular Physiology and Biophysics; Ophthalmology and Visual Sciences
Record Identifier: 9984172264702771

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