Journal article
A Comparison Between Diagnostic I-123 and Posttherapy I-131 Scans in the Detection of Remnant and Locoregional Thyroid Disease
Clinical nuclear medicine, Vol.34(11), pp.745-748
11/2009
DOI: 10.1097/RLU.0b013e3181b7dbb1
PMID: 19851166
Abstract
AIM OF STUDY:The aim of this study was to compare pretherapy diagnostic I-123 scans with 7-day posttherapy I-131 scans days in detecting remnant thyroid disease as well as locoregional metastases in patients who had undergone thyroidectomy for differentiated thyroid cancer.
METHODS:The I-123 and I-131 scans from 53 patients were reviewed. The number of lesions identified on each scan was compared as well as the relative intensity of each lesion on the I-123 and I-131 scans using region-of-interest-derived lesion to background ratios. For the I-123 diagnostic scans, 1.0 to 1.6 mCi of activity was administered orally 24 hours before scan acquisition. Patients received therapeutic doses of I-131 ranging from 30.7 to 362.2 mCi orally, on the same day but after acquisition of the I-123 scan. All posttherapy I-131 scans were performed 7days after radioablative therapy with I-131.
RESULTS:Of the 53 patients, 14 had concordant scans, with an equal number of lesions detected by both scans. Thirty-nine I-123/I-131 scan pairs showed discordance, with 27 patients demonstrating more lesions on the I-123 scans. Of the 142 total lesions, 35% were detected only by I-123 pretherapy images compared with 15% detected only on posttherapy images. In a subgroup of 42 patients I-123 scans showed 56 lesions (out of a total of 116) that demonstrated either a better lesion to background ratio than I-131 or were seen exclusively by I-123.
CONCLUSION:The use of diagnostic I-123 pretherapy scintigraphy seems to be superior in many patients to posttherapy I-131 imaging obtained at 7 days in detecting locoregional metastases or remnant in postsurgical patients. This is likely due to the fact that 1 week is too long to wait to perform posttherapy imaging.
Details
- Title: Subtitle
- A Comparison Between Diagnostic I-123 and Posttherapy I-131 Scans in the Detection of Remnant and Locoregional Thyroid Disease
- Creators
- Damita Thomas - From the Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals and Clinics, Iowa city, IA; and †Department of Radiology, Division of Nuclear Medicine, Iowa City Veterans Medical Center, Diagnostic Imaging Service, Iowa City, IAYusuf MendaDavid Bushnell
- Resource Type
- Journal article
- Publication Details
- Clinical nuclear medicine, Vol.34(11), pp.745-748
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/RLU.0b013e3181b7dbb1
- PMID
- 19851166
- ISSN
- 0363-9762
- eISSN
- 1536-0229
- Language
- English
- Date published
- 11/2009
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984046810502771
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