Journal article
A Comprehensive Echocardiographic Protocol for Assessing Neonatal Right Ventricular Dimensions and Function in the Transitional Period: Normative Data and Z Scores
Journal of the American Society of Echocardiography, Vol.27(12), pp.1293-1304
12/2014
DOI: 10.1016/j.echo.2014.08.018
PMID: 25260435
Abstract
There is a paucity of echocardiographic data describing right ventricular (RV) dimensions and function in the early transitional newborn period.
Fifty healthy term newborns underwent serial echocardiography at a mean of 15 ± 2 and 35 ± 2 hours of age. RV dimensions and functional indices were measured as recommended in the American Society of Echocardiography’s recent guidelines. Additional novel parameters included RV anteroinferior basal diameter, fractional area change (FAC) from the apical three-chamber view, and speckle-tracking echocardiography–derived peak longitudinal strain in the RV lateral (apical four-chamber view) and inferior (apical three-chamber view) walls. Results obtained at both time points were compared.
Linear dimensions and tissue Doppler velocities were highly reproducible, while time intervals and FAC measurements were more variable. Three-chamber FAC was higher than four-chamber FAC (36 ± 5% vs. 24 ± 7%, P < .001). Lateral wall peak longitudinal strain was similar to the value for the inferior wall (22 ± 4% vs 18 ± 5%, P > .05). A small increase in RV dimensions was noted on day 2 of life (midcavity diameter, 1.71 ± 0.19 vs 1.55 ± 0.19 cm, P < .01; RV anteroinferior basal diameter, 2.24 ± 0.29 vs 2.06 ± 0.24 cm, P < .01; end-diastolic-area in the apical four-chamber view, 4.32 ± 0.64 vs 4.10 ± 0.69 cm2, P = .04), while no changes occurred in functional indices. RV dimensions and FAC showed moderate linear correlations with birth weight. Z scores could be computed for the majority of measured indices.
Using conventional and novel indices, the investigators describe a comprehensive echocardiographic protocol for neonatal RV imaging, establish reference ranges, and describe the effect of physiologic postnatal transition on RV dimensions and function. This will facilitate future investigations of RV dysfunction in neonatal cardiopulmonary disorders.
Details
- Title: Subtitle
- A Comprehensive Echocardiographic Protocol for Assessing Neonatal Right Ventricular Dimensions and Function in the Transitional Period: Normative Data and Z Scores
- Creators
- Amish Jain - Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, CanadaAdel Mohamed - Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, CanadaAfif El-Khuffash - Department of Pediatrics, The Rotunda Hospital, Dublin, IrelandKim A Connelly - University of Toronto, Toronto, Ontario, CanadaFrederic Dallaire - The Labatt Family Heart Center, The Hospital for Sick Children, Toronto, Ontario, CanadaRobert P Jankov - University of Toronto, Toronto, Ontario, CanadaPatrick J McNamara - University of Toronto, Toronto, Ontario, CanadaLuc Mertens - University of Toronto, Toronto, Ontario, Canada
- Resource Type
- Journal article
- Publication Details
- Journal of the American Society of Echocardiography, Vol.27(12), pp.1293-1304
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.echo.2014.08.018
- PMID
- 25260435
- ISSN
- 0894-7317
- eISSN
- 1097-6795
- Grant note
- Centre de Recherche Clinique Étienne-Le Bel MOP #93596; 84290 / Canadian Institutes of Health Research (http://dx.doi.org/10.13039/501100000024)
- Language
- English
- Date published
- 12/2014
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984093309302771
Metrics
17 Record Views