Journal article
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
Cancer cell, Vol.33(4), pp.690-705.e9
04/09/2018
DOI: 10.1016/j.ccell.2018.03.014
PMCID: PMC5959730
PMID: 29622464
Abstract
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories.
Details
- Title: Subtitle
- A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
- Creators
- Ashton C Berger - Massachusetts Institute of TechnologyAnil Korkut - The University of Texas MD Anderson Cancer CenterRupa S Kanchi - The University of Texas MD Anderson Cancer CenterApurva M Hegde - The University of Texas MD Anderson Cancer CenterWalter Lenoir - The University of Texas MD Anderson Cancer CenterWenbin Liu - The University of Texas MD Anderson Cancer CenterYuexin Liu - The University of Texas MD Anderson Cancer CenterHuihui Fan - Van Andel InstituteHui Shen - Van Andel InstituteVisweswaran Ravikumar - The University of Texas MD Anderson Cancer CenterArvind Rao - The University of Texas MD Anderson Cancer CenterAndre Schultz - The University of Texas MD Anderson Cancer CenterXubin Li - The University of Texas MD Anderson Cancer CenterPavel Sumazin - Baylor College of MedicineCecilia Williams - KTH Royal Institute of TechnologyPieter Mestdagh - Ghent UniversityPreethi H Gunaratne - Baylor College of MedicineChristina Yau - University of California, San FranciscoReanne Bowlby - BC Cancer AgencyA Gordon Robertson - BC Cancer AgencyDaniel G Tiezzi - Universidade de São PauloChen Wang - Mayo ClinicAndrew D Cherniack - Massachusetts Institute of TechnologyAndrew K Godwin - University of KansasNicole M Kuderer - University of WashingtonJanet S Rader - Medical College of WisconsinRosemary E Zuna - University of OklahomaAnil K Sood - The University of Texas MD Anderson Cancer CenterAlexander J Lazar - The University of Texas MD Anderson Cancer CenterAkinyemi I Ojesina - University of Alabama at BirminghamClement Adebamowo - University of Maryland, BaltimoreSally N Adebamowo - University of Maryland, BaltimoreKeith A Baggerly - The University of Texas MD Anderson Cancer CenterTing-Wen Chen - Baylor College of MedicineHua-Sheng Chiu - Baylor College of MedicineSteve Lefever - Ghent UniversityLiang Liu - Atrium Health Wake Forest BaptistKaren MacKenzie - University of South WalesSandra Orsulic - Cedars-Sinai Medical CenterJason Roszik - The University of Texas MD Anderson Cancer CenterCarl Simon Shelley - Leukemia Therapeutics, LLC, Hull, MA 02045, USA.Qianqian Song - Atrium Health Wake Forest BaptistChristopher P Vellano - The University of Texas MD Anderson Cancer CenterNicolas Wentzensen - National Cancer InstituteJohn N Weinstein - The University of Texas MD Anderson Cancer CenterGordon B Mills - The University of Texas MD Anderson Cancer CenterDouglas A Levine - York UniversityRehan Akbani - The University of Texas MD Anderson Cancer Center
- Contributors
- Cancer Genome Atlas Research Network (Contributor)Deqin Ma (Contributor) - University of Iowa, PathologyMohammed M Milhem (Contributor) - University of Iowa, Internal MedicineAaron D Bossler (Contributor) - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- Cancer cell, Vol.33(4), pp.690-705.e9
- DOI
- 10.1016/j.ccell.2018.03.014
- PMID
- 29622464
- PMCID
- PMC5959730
- NLM abbreviation
- Cancer Cell
- ISSN
- 1535-6108
- eISSN
- 1878-3686
- Grant note
- U24 CA143843 / NCI NIH HHS P50 CA217685 / NCI NIH HHS U01 CA168394 / NCI NIH HHS U24 CA199461 / NCI NIH HHS U24 CA210957 / NCI NIH HHS U54 HG003079 / NHGRI NIH HHS P30 CA016672 / NCI NIH HHS U24 CA143883 / NCI NIH HHS U24 CA210990 / NCI NIH HHS U24 CA143799 / NCI NIH HHS P50 CA098258 / NCI NIH HHS U24 CA143867 / NCI NIH HHS U24 CA143858 / NCI NIH HHS U01 CA217842 / NCI NIH HHS U24 CA143882 / NCI NIH HHS U54 HG003067 / NHGRI NIH HHS U24 CA143845 / NCI NIH HHS P50 CA136393 / NCI NIH HHS U24 CA143835 / NCI NIH HHS U54 HG003273 / NHGRI NIH HHS U24 CA143840 / NCI NIH HHS U24 CA144025 / NCI NIH HHS U24 CA210950 / NCI NIH HHS U24 CA143866 / NCI NIH HHS U24 CA210949 / NCI NIH HHS P30 CA016087 / NCI NIH HHS R01 CA163722 / NCI NIH HHS U24 CA143848 / NCI NIH HHS
- Language
- English
- Date published
- 04/09/2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine
- Record Identifier
- 9984184007502771
Metrics
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