Journal article
A Controlled Study of Repetitive Transcranial Magnetic Stimulation as a Treatment of Depression in the Elderly
International psychogeriatrics, Vol.13(2), pp.225-231
06/2001
DOI: 10.1017/S1041610201007608
PMID: 11495396
Abstract
Rapid transcranial magnetic stimulation (rTMS) applied to the left dorsal lateral frontal cortex has been shown to produce antidepressant effects. Older depressed patients, however, in one study showed a lower response rate than younger patients. The current study examined treatment response in 20 depressed, treatment-refractory patients (mean age 60.7 ± 9.8 years) given five sessions of rTMS at 20 Hz for 2 seconds over 20 trains at 80% of motor threshold or identical placebo stimulation, after patients had been withdrawn from their antidepressants. There were no significant differences in Hamilton Depression Scale scores either before or after treatment at 7 days' follow-up. There were three responders to active treatment and three to sham treatment and responders had significantly greater frontal lobe volume than nonresponders (p=.03). These findings suggest that the stimulation parameters used in this study were probably insufficient to produce treatment response and that frontal atrophy may interfere with the effectiveness of rTMS.
Details
- Title: Subtitle
- A Controlled Study of Repetitive Transcranial Magnetic Stimulation as a Treatment of Depression in the Elderly
- Creators
- Facundo Manes - Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa, USARicardo Jorge - Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa, USAMaria Morcuende - Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa, USAToru Yamada - Department of Neurology, The University of Iowa College of Medicine, Iowa City, Iowa, USASergio Paradiso - Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa, USARobert G Robinson - Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- International psychogeriatrics, Vol.13(2), pp.225-231
- DOI
- 10.1017/S1041610201007608
- PMID
- 11495396
- NLM abbreviation
- Int Psychogeriatr
- ISSN
- 1041-6102
- eISSN
- 1741-203X
- Publisher
- Cambridge University Press; Cambridge, UK
- Number of pages
- 7
- Language
- English
- Date published
- 06/2001
- Academic Unit
- Neurology; Psychiatry
- Record Identifier
- 9984003962502771
Metrics
36 Record Views