Journal article
A DOTA–peptide conjugate by copper-free click chemistry
Bioorganic & medicinal chemistry letters, Vol.20(16), pp.4805-4807
2010
DOI: 10.1016/j.bmcl.2010.06.111
PMCID: PMC3774834
PMID: 20630750
Abstract
Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with 111In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity.
Details
- Title: Subtitle
- A DOTA–peptide conjugate by copper-free click chemistry
- Creators
- Molly E Martin - Department of Pediatrics, Carver College of Medicine, University of Iowa, 4235 MERF 375 Newton Road, Iowa City, IA 52242, USASharavathi G Parameswarappa - Department of Chemistry, University of Iowa, E557 CB, Iowa City, IA 52242, USAM. Sue O’Dorisio - Department of Pediatrics, Carver College of Medicine, University of Iowa, 4235 MERF 375 Newton Road, Iowa City, IA 52242, USAF. Christopher Pigge - Department of Chemistry, University of Iowa, E557 CB, Iowa City, IA 52242, USAMichael K Schultz - Departments of Radiology and Radiation Oncology, Carver College of Medicine, University of Iowa, B180 ML, 500 Newton Road, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.20(16), pp.4805-4807
- DOI
- 10.1016/j.bmcl.2010.06.111
- PMID
- 20630750
- PMCID
- PMC3774834
- NLM abbreviation
- Bioorg Med Chem Lett
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2010
- Academic Unit
- Radiology; Stead Family Department of Pediatrics; Radiation Oncology; Pharmacy Practice and Science; Chemistry
- Record Identifier
- 9983985870702771
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