Journal article
A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss
Hearing research, Vol.332, pp.137-150
02/2016
DOI: 10.1016/j.heares.2015.11.006
PMID: 26631688
Abstract
Distortion product otoacoustic emissions (DPOAEs) were used to assess outer hair cell (OHC) integrity in human ears with age-related hearing loss. Sound pressure measurements were made in the ear canal over the stimulus range 40–90 dB SPL (L2), with L1 = 0.45*L2 + 44 with F2 = 2 and 3 or 4 kHz. Model-generated DPOAE I/O functions were fit to DPOAE data to quantify the contribution of loss of nonlinearity (OHC loss) to the hearing loss. Results suggest OHC loss as a contributing cause of age-related hearing, regardless of audiogram configuration. It seems likely that OHC and strial pathology co-exist in ears with AHL.
•DPOAEs can be used to assess OHC integrity.•A loss of cochlear amplification can be modeled with/without a loss of nonlinearity.•In humans, it seems likely that OHC and strial pathology co-exist in ears with AHL.
Details
- Title: Subtitle
- A DPOAE assessment of outer hair cell integrity in ears with age-related hearing loss
- Creators
- Margarete A Ueberfuhr - Graduate School of Systemic Neurosciences, Ludwig-Maximilians University, Munich, GermanyHannah Fehlberg - Audiology and Aural Rehabilitation, University of Minnesota Medical Center, Minneapolis, MN, 55455, USAShawn S Goodman - Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, 52242, USARobert H Withnell - Department of Speech and Hearing Sciences, Indiana University, Bloomington, IN, 47405, USA
- Resource Type
- Journal article
- Publication Details
- Hearing research, Vol.332, pp.137-150
- DOI
- 10.1016/j.heares.2015.11.006
- PMID
- 26631688
- NLM abbreviation
- Hear Res
- ISSN
- 0378-5955
- eISSN
- 1878-5891
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 02/2016
- Academic Unit
- Communication Sciences and Disorders
- Record Identifier
- 9984002466302771
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