Journal article
A Data-Driven Investigation of Gray Matter–Function Correlations in Schizophrenia during a Working Memory Task
Frontiers in human neuroscience, Vol.5, 71
08/05/2011
DOI: 10.3389/fnhum.2011.00071
PMCID: PMC3153862
PMID: 21886614
Abstract
The brain is a vastly interconnected organ and methods are needed to investigate its long range structure(S)–function(F) associations to better understand disorders such as schizophrenia that are hypothesized to be due to distributed disconnected brain regions. In previous work we introduced a methodology to reduce the whole brain S–F correlations to a histogram and here we reduce the correlations to brain clusters. The application of our approach to sMRI [gray matter (GM) concentration maps] and functional magnetic resonance imaging data (general linear model activation maps during
Encode
and
Probe
epochs of a working memory task) from patients with schizophrenia (SZ,
n
= 100) and healthy controls (HC,
n
= 100) presented the following results. In HC the whole brain correlation histograms for GM–
Encode
and GM–
Probe
overlap for
Low
and
Medium
loads and at
High
the histograms separate, but in SZ the histograms do not overlap for any of the load levels and
Medium
load shows the maximum difference. We computed GM–F differential correlation clusters using activation for
Probe Medium
, and they included regions in the left and right superior temporal gyri, anterior cingulate, cuneus, middle temporal gyrus, and the cerebellum. Inter-cluster GM–
Probe
correlations for
Medium
load were positive in HC but negative in SZ. Within group inter-cluster GM–
Encode
and GM–
Probe
correlation comparisons show no differences in HC but in SZ differences are evident in the same clusters where HC vs. SZ differences occurred for
Probe Medium
, indicating that the S–F integrity during
Probe
is aberrant in SZ. Through a data-driven whole brain analysis approach we find novel brain clusters and show how the S–F differential correlation changes during
Probe
and
Encode
at three memory load levels. Structural and functional anomalies have been extensively reported in schizophrenia and here we provide evidences to suggest that evaluating S–F associations can provide important additional information.
Details
- Title: Subtitle
- A Data-Driven Investigation of Gray Matter–Function Correlations in Schizophrenia during a Working Memory Task
- Creators
- Andrew M Michael - The Mind Research NetworkMargaret D King - The Mind Research NetworkStefan Ehrlich - Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Dresden University of TechnologyGodfrey Pearlson - Olin Center, Institute of LivingTonya White - Department of Psychiatry, University of MinnesotaDaphne J Holt - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical SchoolNancy C Andreasen - Department of Psychiatry, University of IowaUnal Sakoglu - Center for Vital Longevity, University of Texas at DallasBeng-Choon Ho - Department of Psychiatry, University of IowaS. Charles Schulz - Department of Psychiatry, University of MinnesotaVince D Calhoun - Department of Electrical and Computer Engineering, University of New Mexico
- Resource Type
- Journal article
- Publication Details
- Frontiers in human neuroscience, Vol.5, 71
- DOI
- 10.3389/fnhum.2011.00071
- PMID
- 21886614
- PMCID
- PMC3153862
- NLM abbreviation
- Front Hum Neurosci
- ISSN
- 1662-5161
- eISSN
- 1662-5161
- Publisher
- Frontiers Research Foundation
- Language
- English
- Date published
- 08/05/2011
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003904602771
Metrics
29 Record Views