Journal article
A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection
The Journal of experimental medicine, Vol.193(6), pp.671-678
03/19/2001
DOI: 10.1084/jem.193.6.671
PMCID: PMC2193415
PMID: 11257134
Abstract
The discovery of dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3–grabbing nonintegrin (DC-SIGN) as a DC-specific ICAM-3 binding receptor that enhances HIV-1 infection of T cells in trans has indicated a potentially important role for adhesion molecules in AIDS pathogenesis. A related molecule called DC-SIGNR exhibits 77% amino acid sequence identity with DC-SIGN. The
DC-SIGN
and
DC-SIGNR
genes map within a 30-kb region on chromosome 19p13.2-3. Their strong homology and close physical location indicate a recent duplication of the original gene. Messenger RNA and protein expression patterns demonstrate that the DC-SIGN–related molecule is highly expressed on liver sinusoidal cells and in the lymph node but not on DCs, in contrast to DC-SIGN. Therefore, we suggest that a more appropriate name for the DC-SIGN–related molecule is L-SIGN, liver/lymph node–specific ICAM-3–grabbing nonintegrin. We show that in the liver, L-SIGN is expressed by sinusoidal endothelial cells. Functional studies indicate that L-SIGN behaves similarly to DC-SIGN in that it has a high affinity for ICAM-3, captures HIV-1 through gp120 binding, and enhances HIV-1 infection of T cells in trans. We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1.
Details
- Title: Subtitle
- A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection
- Creators
- Arman A Bashirova - Laboratory of Genomic Diversity, Science Applications International Corporation-FrederickTeunis B.H Geijtenbeek - Tumor Immunology Department, University Medical Center St. Radbound, Nijmegen 6525 EX, The NetherlandsGerard C.F van Duijnhoven - Tumor Immunology Department, University Medical Center St. Radbound, Nijmegen 6525 EX, The NetherlandsSandra J van Vliet - Tumor Immunology Department, University Medical Center St. Radbound, Nijmegen 6525 EX, The NetherlandsJeroen B.G Eilering - Tumor Immunology Department, University Medical Center St. Radbound, Nijmegen 6525 EX, The NetherlandsMaureen P Martin - Intramural Research Support Program, Science Applications International Corporation-FrederickLi Wu - HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland 21702Thomas D Martin - HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland 21702Nicola Viebig - Zentrum für Moleculare Biologie Heidelberg (ZMBH), D-69120 Heidelberg, GermanyPercy A Knolle - Zentrum für Moleculare Biologie Heidelberg (ZMBH), D-69120 Heidelberg, GermanyVineet N KewalRamani - HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland 21702Yvette van Kooyk - Tumor Immunology Department, University Medical Center St. Radbound, Nijmegen 6525 EX, The NetherlandsMary Carrington - Intramural Research Support Program, Science Applications International Corporation-Frederick
- Resource Type
- Journal article
- Publication Details
- The Journal of experimental medicine, Vol.193(6), pp.671-678
- Publisher
- The Rockefeller University Press
- DOI
- 10.1084/jem.193.6.671
- PMID
- 11257134
- PMCID
- PMC2193415
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- Language
- English
- Date published
- 03/19/2001
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001156502771
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