Journal article
A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020
Journal of the Pediatric Infectious Diseases Society, Vol.11(5), pp.191-198
05/30/2022
DOI: 10.1093/jpids/piab123
PMCID: PMC8807297
PMID: 35022779
Abstract
It is unclear how acute coronavirus disease 2019 (COVID-19)-directed therapies are used in children with life-threatening COVID-19 in US hospitals. We described characteristics of children hospitalized in the intensive care unit or step-down unit (ICU/SDU) who received COVID-19-directed therapies and the specific therapies administered.
Between March 15, 2020 and December 27, 2020, children <18 years of age in the ICU/SDU with acute COVID-19 at 48 pediatric hospitals in the United States were identified. Demographics, laboratory values, and clinical course were compared in children who did and did not receive COVID-19-directed therapies. Trends in COVID-19-directed therapies over time were evaluated.
Of 424 children in the ICU/SDU, 235 (55%) received COVID-19-directed therapies. Children who received COVID-19-directed therapies were older than those who did not receive COVID-19-directed therapies (13.3 [5.6-16.2] vs 9.8 [0.65-15.9] years), more had underlying medical conditions (188 [80%] vs 104 [55%]; difference = 25% [95% CI: 16% to 34%]), more received respiratory support (206 [88%] vs 71 [38%]; difference = 50% [95% CI: 34% to 56%]), and more died (8 [3.4%] vs 0). Of the 235 children receiving COVID-19-directed therapies, 172 (73%) received systemic steroids and 150 (64%) received remdesivir, with rising remdesivir use over the study period (14% in March/April to 57% November/December).
Despite the lack of pediatric data evaluating treatments for COVID-19 in critically ill children, more than half of children requiring intensive or high acuity care received COVID-19-directed therapies.
Details
- Title: Subtitle
- A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020
- Creators
- Jennifer E Schuster - Children's Mercy HospitalNatasha B Halasa - Vanderbilt University Medical CenterMari Nakamura - Harvard UniversityEmily R Levy - Mayo Clinic in FloridaJulie C Fitzgerald - University of PennsylvaniaCameron C Young - Boston Children's HospitalMargaret M Newhams - Boston Children's HospitalFlorence Bourgeois - Boston Children's HospitalMary A Staat - Cincinnati Children's Hospital Medical CenterCharlotte V Hobbs - University of Mississippi Medical CenterHeda Dapul - Morgan Stanley Children's HospitalLeora R Feldstein - Centers for Disease Control and PreventionAshley M Jackson - Centers for Disease Control and PreventionElizabeth H Mack - Medical University of South CarolinaTracie C Walker - University of North Carolina at Chapel HillAline B Maddux - Children's Hospital ColoradoPhilip C Spinella - Washington University in St. LouisLaura L Loftis - Texas Children's HospitalMichele Kong - University of Alabama at BirminghamCourtney M Rowan - Riley Hospital for ChildrenMelania M Bembea - Johns Hopkins MedicineGwenn E McLaughlin - University of MiamiMark W Hall - Nationwide Children's HospitalChristopher J Babbitt - Miller Children's & Women's HospitalMia Maamari - The University of Texas Southwestern Medical CenterMatt S Zinter - University of California, San FranciscoNatalie Z Cvijanovich - UCSF Benioff Children's HospitalKelly N Michelson - Lurie Children's HospitalShira J Gertz - Saint Barnabas Medical CenterChristopher L Carroll - Connecticut Children's Medical CenterNeal J Thomas - Penn State Milton S. Hershey Medical CenterJohn S Giuliano - Yale UniversityAalok R Singh - Maria Fareri Children's HospitalSaul R Hymes - Stony Brook Children's HospitalAdam J Schwarz - Children's Hospital of Orange CountyJohn K McGuire - University of WashingtonRyan A Nofziger - Akron Children's HospitalHeidi R Flori - C. S. Mott Children's HospitalKatharine N Clouser - Hackensack Meridian HealthKari Wellnitz - University of IowaMelissa L Cullimore - Children's Hospital & Medical CenterJanet R Hume - University of MinnesotaManish Patel - Centers for Disease Control and PreventionAdrienne G Randolph - Harvard UniversityOvercoming COVID-19 Investigators
- Resource Type
- Journal article
- Publication Details
- Journal of the Pediatric Infectious Diseases Society, Vol.11(5), pp.191-198
- DOI
- 10.1093/jpids/piab123
- PMID
- 35022779
- PMCID
- PMC8807297
- ISSN
- 2048-7193
- eISSN
- 2048-7207
- Grant note
- UL1 TR001863 / NCATS NIH HHS K23119463 / NIH HHS United States Centers for Disease Control and Prevention CDC HHS K23 HL150244 / NHLBI NIH HHS Burroughs Welcome Fund Innovation in Regulatory Science Award
- Language
- English
- Date published
- 05/30/2022
- Academic Unit
- Critical Care; Stead Family Department of Pediatrics
- Record Identifier
- 9984353830302771
Metrics
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