A Drosophila mutant with a temperature-sensitive block in nerve conduction

Chun-Fang Wu; Barry Ganetzky; Lily Yeh Jan; Yuh Nung Jan; Seymour Benzer

doi:10.1073/pnas.75.8.4047

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A Drosophila mutant with a temperature-sensitive block in nerve conduction

Journal article

Open access

Peer reviewed

A Drosophila mutant with a temperature-sensitive block in nerve conduction

Chun-Fang Wu, Barry Ganetzky, Lily Yeh Jan, Yuh Nung Jan and Seymour Benzer

Proceedings of the National Academy of Sciences - PNAS, Vol.75(8), pp.4047-4051

08/1978

DOI: 10.1073/pnas.75.8.4047

PMCID: PMC392928

PMID: 211514

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Abstract

A mutant, napts (no action potential, temperature-sensitive), is described in which axonal conduction fails at high temperature. Synaptic transmission at the larval neuromuscular junction is unimpaired. Larvae and adults are rapidly paralyzed at restrictive temperatures; they recover rapidly when the temperature is decreased. The mutant gene is recessive and is located on the second chromosome at map position 56.

Mutation

Synaptic Transmission

Action Potentials

Animals

Chromosome Mapping

Drosophila - genetics

Genes, Recessive

Larva

Neural Conduction

Temperature

Details

Title: Subtitle: A Drosophila mutant with a temperature-sensitive block in nerve conduction
Creators: Chun-Fang Wu - University of Iowa, Biology
Barry Ganetzky
Lily Yeh Jan
Yuh Nung Jan
Seymour Benzer
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.75(8), pp.4047-4051
DOI: 10.1073/pnas.75.8.4047
PMID: 211514
PMCID: PMC392928
ISSN: 0027-8424
eISSN: 1091-6490
Language: English
Date published: 08/1978
Academic Unit: Iowa Neuroscience Institute; Biology
Record Identifier: 9984216456402771

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