Journal article
A Drosophila mutation that eliminates a calcium-dependent potassium current
Proceedings of the National Academy of Sciences - PNAS, Vol.83(21), pp.8415-8419
1986
DOI: 10.1073/pnas.83.21.8415
PMCID: PMC386939
PMID: 2430288
Abstract
A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+ current, IC, from dorsal longitudinal flight muscles of adult flies. Other K+ currents remain normal, providing evidence that IC is mediated by a molecularly distinguishable set of channels. The pharmacological properties of IC are similar to those of Ca2+-dependent currents in some vertebrate cells. The muscle action potential was significantly lengthened in slo flies, indicating that IC plays the major role in its repolarization.
Details
- Title: Subtitle
- A Drosophila mutation that eliminates a calcium-dependent potassium current
- Creators
- Thomas Elkins - Univ. Wisconsin, dep. zoology, Madison WI 53706, United StatesBarry Ganetzky - Univ. Wisconsin, dep. zoology, Madison WI 53706, United StatesChun-Fang Wu - Univ. Wisconsin, dep. zoology, Madison WI 53706, United States
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.83(21), pp.8415-8419
- DOI
- 10.1073/pnas.83.21.8415
- PMID
- 2430288
- PMCID
- PMC386939
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences of the United States of America; Washington, DC
- Language
- English
- Date published
- 1986
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070351902771
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