Journal article
A-FABP Decreases in the Wean Milk of Nursing Women with a Family History of Breast Cancer
International Journal of Women's Health and Wellness, Vol.3(4), 063
09/30/2017
DOI: 10.23937/2474-1353/1510063
Abstract
Adipocyte/Macrophage Fatty Acid Binding Protein (A-FABP) is linked to breast cancer. Proteins up regulated in breast cancer tissue are often increased in milk from women with and at increased risk of developing breast cancer. We measured A-FABP in human milk from 76 lactating women based on a) Phase of lactation (within 10 days of delivery: transitional-T, mid: 2 month, and wean-W), b) Family history, c) Body mass index, d) Age, and e) Age at First Full Term Pregnancy (FFTP). A-FABP expression was a) Lower in 2 month than T milk independent of family history (p < 0.01), b) Lower in 2 month than W milk only in women without a family history (p < 0.01), and c) Lower in W than T milk only in women with a family history (p = 0.055). A-FABP was not associated with body mass index, age, or FFTP. Lower A-FABP in W than T milk only in women with a family history of breast cancer suggests breastfeeding has a greater breast cancer protective effect in women with than without a family history.
Details
- Title: Subtitle
- A-FABP Decreases in the Wean Milk of Nursing Women with a Family History of Breast Cancer
- Creators
- Bing LiJiaqing HaoXiaofang YanMaiying KongEdward R Sauter
- Resource Type
- Journal article
- Publication Details
- International Journal of Women's Health and Wellness, Vol.3(4), 063
- DOI
- 10.23937/2474-1353/1510063
- ISSN
- 2474-1353
- eISSN
- 2474-1353
- Language
- English
- Date published
- 09/30/2017
- Academic Unit
- Pathology
- Record Identifier
- 9984695785602771
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