Journal article
A FDG-PET Study of Metabolic Networks in Apolipoprotein E ε4 Allele Carriers
PloS one, Vol.10(7), pp.e0132300-e0132300
2015
DOI: 10.1371/journal.pone.0132300
PMCID: PMC4498596
PMID: 26161964
Abstract
Recently, some studies have applied the graph theory in brain network analysis in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). However, relatively little research has specifically explored the properties of the metabolic network in apolipoprotein E (APOE) ε4 allele carriers. In our study, all the subjects, including ADs, MCIs and NCs (normal controls) were divided into 165 APOE ε4 carriers and 165 APOE ε4 noncarriers. To establish the metabolic network for all brain regions except the cerebellum, cerebral glucose metabolism data obtained from FDG-PET (18F-fluorodeoxyglucose positron emission tomography) were segmented into 90 areas with automated anatomical labeling (AAL) template. Then, the properties of the networks were computed to explore the between-group differences. Our results suggested that both APOE ε4 carriers and noncarriers showed the small-world properties. Besides, compared with APOE ε4 noncarriers, the carriers showed a lower clustering coefficient. In addition, significant changes in 6 hub brain regions were found in between-group nodal centrality. Namely, compared with APOE ε4 noncarriers, significant decreases of the nodal centrality were found in left insula, right insula, right anterior cingulate, right paracingulate gyri, left cuneus, as well as significant increases in left paracentral lobule and left heschl gyrus in APOE ε4 carriers. Increased local short distance interregional correlations and disrupted long distance interregional correlations were found, which may support the point that the APOE ε4 carriers were more similar with AD or MCI in FDG uptake. In summary, the organization of metabolic network in APOE ε4 carriers indicated a less optimal pattern and APOE ε4 might be a risk factor for AD.
Details
- Title: Subtitle
- A FDG-PET Study of Metabolic Networks in Apolipoprotein E ε4 Allele Carriers
- Creators
- Zhijun Yao - School of Information Science and Engineering, Lanzhou University, Lanzhou, ChinaBin Hu - School of Information Science and Engineering, Lanzhou University, Lanzhou, ChinaJiaxiang Zheng - School of Information Science and Engineering, Lanzhou University, Lanzhou, ChinaWeihao Zheng - School of Information Science and Engineering, Lanzhou University, Lanzhou, ChinaXuejiao Chen - School of Information Science and Engineering, Lanzhou University, Lanzhou, ChinaXiang Gao - School of Information Science and Engineering, Lanzhou University, Lanzhou, ChinaYuanwei Xie - School of Information Science and Engineering, Lanzhou University, Lanzhou, ChinaLei Fang - PET/CT Center, Affiliated Lanzhou General Hospital of Lanzhou Military Area Command, 333 South Binhe Road, Lanzhou, ChinaAlzheimer’s Disease Neuroimaging Initiative
- Contributors
- Laura L Boles-Ponto (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- PloS one, Vol.10(7), pp.e0132300-e0132300
- DOI
- 10.1371/journal.pone.0132300
- PMID
- 26161964
- PMCID
- PMC4498596
- NLM abbreviation
- PLoS One
- ISSN
- 1932-6203
- eISSN
- 1932-6203
- Publisher
- Public Library of Science; United States
- Grant note
- P30 AG062421 / NIA NIH HHS P50 AG005134 / NIA NIH HHS
- Language
- English
- Date published
- 2015
- Academic Unit
- Radiology; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984051573502771
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