Journal article
A Family-Based Genome Wide Association Study of Externalizing Behaviors
Behavior genetics, Vol.50(3), pp.175-183
05/01/2020
DOI: 10.1007/s10519-020-09999-3
PMCID: PMC7243710
PMID: 32239439
Abstract
Shared genetic factors contribute to the high degree of comorbidity among externalizing problems (e.g. substance use and antisocial behavior). We leverage this common genetic etiology to identify genetic influences externalizing problems in participants from the Collaborative Study on the Genetics of Alcoholism (European ancestry = 7568; African ancestry = 3274). We performed a family-based genome-wide association study (GWAS) on externalizing scores derived from criterion counts of five DSM disorders (alcohol dependence, alcohol abuse, illicit drug dependence, illicit drug abuse, and either antisocial personality disorder or conduct disorder). We meta analyzed these results with a similar measure of externalizing in an independent sample, Spit for Science (combined sample N = 15,112). We did not discover any robust genome-wide significant signals. Polygenic scores derived from the ancestry-specific GWAS summary statistics predicted externalizing problems in an independent European ancestry sample, but not in those of African ancestry. However, these PRS were no longer significant after adjusting for multiple testing. Larger samples with deep phenotyping are necessary for the discovery of SNPs related to externalizing problems.
Details
- Title: Subtitle
- A Family-Based Genome Wide Association Study of Externalizing Behaviors
- Creators
- Peter B. Barr - Virginia Commonwealth UniversityJessica E. Salvatore - Virginia Commonwealth UniversityLeah Wetherill - Indiana University – Purdue University IndianapolisAndrey Anokhin - Washington University in St. LouisGrace Chan - University of ConnecticutHoward J. Edenberg - Indiana University – Purdue University IndianapolisSamuel Kuperman - Roy J. and Lucille A. Carver College of MedicineJacquelyn Meyers - SUNY Downstate Health Sciences UniversityJohn Nurnberger - Indiana University – Purdue University IndianapolisBernice Porjesz - SUNY Downstate Health Sciences UniversityMark Schuckit - University of California San DiegoDanielle M. Dick - Virginia Commonwealth University
- Resource Type
- Journal article
- Publication Details
- Behavior genetics, Vol.50(3), pp.175-183
- DOI
- 10.1007/s10519-020-09999-3
- PMID
- 32239439
- PMCID
- PMC7243710
- NLM abbreviation
- Behav Genet
- ISSN
- 0001-8244
- eISSN
- 1573-3297
- Publisher
- Springer Nature
- Number of pages
- 9
- Grant note
- U10AA008401; K02AA018755; K01AA024152 / National Institutes of Health through the National Institute on Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) U10AA008401 / National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission
- Language
- English
- Date published
- 05/01/2020
- Academic Unit
- Psychiatry
- Record Identifier
- 9984293755002771
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