A Fatal Case of West Nile Virus Infection in a Bone Marrow Transplant Recipient

Bradley Hiatt; Lucy DesJardin; Thomas Carter; Roger Gingrich; Curt Thompson; Margarida de Magalhaes-Silverman

doi:10.1086/378891

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A Fatal Case of West Nile Virus Infection in a Bone Marrow Transplant Recipient

Journal article

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A Fatal Case of West Nile Virus Infection in a Bone Marrow Transplant Recipient

Bradley Hiatt, Lucy DesJardin, Thomas Carter, Roger Gingrich, Curt Thompson and Margarida de Magalhaes-Silverman

Clinical infectious diseases, Vol.37(9), pp.e129-e131

11/01/2003

DOI: 10.1086/378891

PMID: 14557983

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Abstract

West Nile virus (WNV) can cause severe, potentially fatal neurological illnesses, which include encephalitis, meningitis, Guillain-Barré syndrome, and anterior myelitis. Because of the short viremic phase, WNV infection is most commonly diagnosed by detection of immunoglobulin M antibody to WNV in serum or cerebrospinal fluid (CSF). We describe a patient with T cell lymphoma who had undergone a T cell-depleted bone marrow transplantation and developed fatal WNV infection. The results of serological tests of blood samples and of CSF tests were negative. Diagnosis was made postmortem by a positive result of reverse-transcriptase polymerase chain reaction (ABI 7700; TaqMan) for WNV in stored CSF and serum samples.

Details

Title: Subtitle: A Fatal Case of West Nile Virus Infection in a Bone Marrow Transplant Recipient
Creators: Bradley Hiatt - Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Internal Medicine, College of Medicine, Iowa City
Lucy DesJardin - Hygienic Laboratory, University of Iowa, Iowa City
Thomas Carter - Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Internal Medicine, College of Medicine, Iowa City
Roger Gingrich - Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Internal Medicine, College of Medicine, Iowa City
Curt Thompson - Hygienic Laboratory, University of Iowa, Iowa City
Margarida de Magalhaes-Silverman - Division of Hematology, Oncology, Blood and Marrow Transplantation, Department of Internal Medicine, College of Medicine, Iowa City
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.37(9), pp.e129-e131
DOI: 10.1086/378891
PMID: 14557983
NLM abbreviation: Clin Infect Dis
ISSN: 1058-4838
eISSN: 1537-6591
Publisher: The University of Chicago Press
Language: English
Date published: 11/01/2003
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
Record Identifier: 9984094518402771

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