Journal article
A Fatal Colchicine Ingestion With Antemortem Blood Concentration
The American journal of forensic medicine and pathology, Vol.43(3), pp.253-255
09/01/2022
DOI: 10.1097/PAF.0000000000000757
PMID: 35353721
Abstract
ABSTRACTAlthough there are multiple therapeutic uses for colchicine, it is particularly dangerous in the setting of overdose due to an irreversible mechanism of action combined with a narrow therapeutic window. Colchicine is an antimitotic agent that binds tubulin and inhibits microtubule polymerization. This produces a predictable sequence of toxicity beginning with gastrointestinal effects with progression to multiorgan system dysfunction. Unfortunately, there are no specific antidotes for colchicine toxicity after organ injury has occurred, which can lead to tragic consequences. Despite the recognized toxicity, it is exceedingly rare to find a case in the medical literature with a confirmed time of ingestion, amount ingested, data from longitudinal examinations, and laboratory assessments, with a quantitative blood colchicine concentration. We present a case of acute colchicine overdose of 18 mg (approximately 0.25 mg/kg) with subsequent multiorgan failure and death with an antemortem blood colchicine concentration of 14 ng/mL at 18.5 hours after ingestion.
Details
- Title: Subtitle
- A Fatal Colchicine Ingestion With Antemortem Blood Concentration
- Creators
- Daniel J McCabeBryan Z WilsonJoshua B RadkeEdward M Bottei
- Resource Type
- Journal article
- Publication Details
- The American journal of forensic medicine and pathology, Vol.43(3), pp.253-255
- DOI
- 10.1097/PAF.0000000000000757
- PMID
- 35353721
- ISSN
- 0195-7910
- eISSN
- 1533-404X
- Language
- English
- Date published
- 09/01/2022
- Academic Unit
- Emergency Medicine; Internal Medicine
- Record Identifier
- 9984296980402771
Metrics
17 Record Views