A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs

Sanghun Choi; Shinjiro Miyawaki; Ching-Long Lin

doi:10.1155/2018/6564854

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A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs

Journal article

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A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs

Sanghun Choi, Shinjiro Miyawaki and Ching-Long Lin

Computational and mathematical methods in medicine, Vol.2018, pp.6564854-12

2018

DOI: 10.1155/2018/6564854

PMCID: PMC6081571

PMID: 30140302

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https://doi.org/10.1155/2018/6564854View

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Abstract

This study aims to investigate the effect of altered structures and functions in severe asthma on particle deposition by using computational fluid dynamics (CFD) models. Airway geometrical models of two healthy subjects and two severe asthmatics were reconstructed from computed tomography (CT) images. Subject-specific flow boundary conditions were obtained by image registration to account for regional functional alterations of severe asthmatics. A large eddy simulation (LES) model for transitional and turbulent flows was applied to simulate airflows, and particle transport simulations were then performed for 2.5, 5, and 10 m particles using CFD-predicted flow fields. Compared to the healthy subjects, the severe asthmatics had a smaller air-volume change in the lower lobes and a larger air-volume change in the upper lobes. Both severe asthmatics had smaller airway circularity ( ), but one of them had a significant reduction of hydraulic diameter ( ). In severe asthmatics, the larger air-volume change in the upper lobes resulted in more particles in the upper lobes, especially for the small 2.5 m particles. The structural alterations measured by and were associated with a higher particle deposition. was found to be the most important metric which affects the specific location of particle deposition. This study demonstrates the relationship of CT-based structural and functional alterations in severe asthma with flow and particle dynamics.

Asthma - diagnostic imaging

Asthma - physiopathology

Computer Simulation

Female

Humans

Hydrodynamics

Lung - diagnostic imaging

Lung - physiopathology

Models, Biological

Particle Size

Tomography, X-Ray Computed

Details

Title: Subtitle: A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs
Creators: Sanghun Choi - Kyungpook National University
Shinjiro Miyawaki - University of Iowa
Ching-Long Lin - University of Iowa
Resource Type: Journal article
Publication Details: Computational and mathematical methods in medicine, Vol.2018, pp.6564854-12
DOI: 10.1155/2018/6564854
PMID: 30140302
PMCID: PMC6081571
NLM abbreviation: Comput Math Methods Med
ISSN: 1748-670X
eISSN: 1748-6718
Grant note: U01 HL114494 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS R01 HL094315 / NHLBI NIH HHS S10 RR022421 / NCRR NIH HHS R01 HL112986 / NHLBI NIH HHS
Language: English
Date published: 2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering
Record Identifier: 9984195169102771

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