Journal article
A Functional Connection Between Inferior Frontal Gyrus and Orofacial Motor Cortex in Human
Journal of neurophysiology, Vol.92(2), pp.1153-1164
08/2004
DOI: 10.1152/jn.00609.2003
PMID: 15056683
Abstract
The inferior frontal gyrus (IFG) of humans is known to play a critical role in speech production. The IFG is a highly convoluted and cytoarchitectonically diverse structure, classically forming 3 subgyri. It is reasonable to speculate that during speaking the IFG, or some portion of it, influences by corticocortical connections the orofacial representational area of primary motor cortex. To test the hypothesis that such corticocortical connections exist, electrical-stimulation tract tracing experiments were performed intraoperatively on 14 human subjects undergoing surgical treatment of medically intractable epilepsy. Bipolar electrical stimulation was applied to sites on the IFG, while the resulting evoked potentials were recorded from orofacial motor cortex, using a multichannel recording array. Stimulation of the IFG evoked polyphasic waveforms on motor cortex of both language-dominant and -nondominant hemispheres. The evoked waveforms had consistent features across subjects. The responses were seen in discrete regions on precentral cortex. Stimulation of motor cortex also evoked responses on portions of IFG. The data provide evidence for a functional connection between the human IFG and orofacial motor cortex.
Details
- Title: Subtitle
- A Functional Connection Between Inferior Frontal Gyrus and Orofacial Motor Cortex in Human
- Creators
- Jeremy D. W Greenlee - Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Hiroyuki Oya - Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Hiroto Kawasaki - Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Igor O Volkov - Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Olaf P Kaufman - Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Christopher Kovach - Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242Matthew A Howard - Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242John F Brugge - Department of Neurosurgery, University of Iowa, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- Journal of neurophysiology, Vol.92(2), pp.1153-1164
- DOI
- 10.1152/jn.00609.2003
- PMID
- 15056683
- ISSN
- 0022-3077
- eISSN
- 1522-1598
- Language
- English
- Date published
- 08/2004
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984020789302771
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