A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster

J WINICK; T ABEL; M. W LEONARD; A. M MICHELSON; I CHARDON-LORIAUX; R A Holmgren; T MANIATIS; J. D ENGEL

doi:10.1242/dev.119.4.1055

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A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster

Journal article

Peer reviewed

A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster

J WINICK, T ABEL, M. W LEONARD, A. M MICHELSON, I CHARDON-LORIAUX, R A Holmgren, T MANIATIS and J. D ENGEL

Development (Cambridge), Vol.119(4), pp.1055-1065

1993

DOI: 10.1242/dev.119.4.1055

PMID: 7916677

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Abstract

The GATA transcription factors are a family of C4 zinc finger-motif DNA-binding proteins that play defined roles in hematopoiesis as well as presumptive roles in other tissues where they are expressed (e.g., testis, neuronal and placental trophoblast cells) during vertebrate development. To investigate the possibility that GATA proteins may also be involved in Drosophila development, we have isolated and characterized a gene (dGATAa) encoding a factor that is quite similar to mammalian GATA factors. The dGATAa protein sequence contains the two zinc finger DNA-binding domain of the GATA class but bears no additional sequence similarity to any of the vertebrate GATA factors. Analysis of dGATAa gene transcription during Drosophila development revealed that its mRNA is expressed at high levels during early embryogenesis, with transcripts first appearing in the dorsal portion of the embryo just after cellularization. As development progresses, dGATAa mRNA is present at high levels in the dorsal epidermis, suggesting that dGATAa may be involved in determining dorsal cell fate. The pattern of expression in a variety of dorsoventral polarity mutants indicates that dGATAa lies downstream of the zygotic patterning genes decapentaplegic and zerknüllt.

Fundamental and applied biological sciences. Psychology

Biochemistry. Physiology. Immunology

Biological and medical sciences

Physiology. Development

Invertebrates

Insecta

Details

Title: Subtitle: A GATA family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster
Creators: J WINICK - Northwestern univ., dep. biochemistry molecular cell biology, Evanston IL, United States
T ABEL - Northwestern univ., dep. biochemistry molecular cell biology, Evanston IL, United States
M. W LEONARD - Northwestern univ., dep. biochemistry molecular cell biology, Evanston IL, United States
A. M MICHELSON - Northwestern univ., dep. biochemistry molecular cell biology, Evanston IL, United States
I CHARDON-LORIAUX - Northwestern univ., dep. biochemistry molecular cell biology, Evanston IL, United States
R A Holmgren - Northwestern univ., dep. biochemistry molecular cell biology, Evanston IL, United States
T MANIATIS - Northwestern univ., dep. biochemistry molecular cell biology, Evanston IL, United States
J. D ENGEL - Northwestern univ., dep. biochemistry molecular cell biology, Evanston IL, United States
Resource Type: Journal article
Publication Details: Development (Cambridge), Vol.119(4), pp.1055-1065
DOI: 10.1242/dev.119.4.1055
PMID: 7916677
NLM abbreviation: Development
ISSN: 0950-1991
eISSN: 1477-9129
Publisher: Company of Biologists; Cambridge
Language: English
Date published: 1993
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984071763502771

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