Journal article
A Gene for Recessive Nonsyndromic Sensorineural Deafness (DFNB18) Maps to the Chromosomal Region 11p14–p15.1 Containing the Usher Syndrome Type 1C Gene
Genomics (San Diego, Calif.), Vol.50(2), pp.290-292
06/01/1998
DOI: 10.1006/geno.1998.5320
PMID: 9653658
Abstract
Autosomal recessive nonsyndromic sensorineural deafness segregating in a large consanguineous Indian family was mapped to chromosome 11p14–p15.1 defining a new locus,DFNB18.A maximum lod score of 4.4 at θ = 0 was obtained for the polymorphic microsatellite markerD11S1888.Haplotype analysis localizes this gene between markersD11S1307andD11S2368,which is approximately 1.6 cM and encompasses the region of Usher syndrome type 1C (USH1C). We postulate thatDFNB18andUSH1Care allelic variants of the same gene.
Details
- Title: Subtitle
- A Gene for Recessive Nonsyndromic Sensorineural Deafness (DFNB18) Maps to the Chromosomal Region 11p14–p15.1 Containing the Usher Syndrome Type 1C Gene
- Creators
- Pawan K Jain - Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland, 20850-3227Anil K Lalwani - Division of Otology, Neurotology, and Skullbase Surgery, Department of Otolaryngology, Head and Neck Surgery, School of Medicine, University of California, San Francisco A730, 400 Parnassus Avenue, San Francisco, California, 94143Xiaoyan C Li - Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland, 20850-3227Teresa L Singleton - Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland, 20850-3227Tenesha N Smith - Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland, 20850-3227Achih Chen - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, Iowa, 52242-1078Dilip Deshmukh - Deshmukh Nursing Home, Sangram Chouk, Ichalkaranji, 416 115, Maharashtra State, IndiaIshwar C Verma - All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110 029, IndiaRichard J.H Smith - Molecular Otolaryngology Research Laboratories, Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, Iowa, 52242-1078Edward R Wilcox - Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, Maryland, 20850-3227
- Resource Type
- Journal article
- Publication Details
- Genomics (San Diego, Calif.), Vol.50(2), pp.290-292
- DOI
- 10.1006/geno.1998.5320
- PMID
- 9653658
- NLM abbreviation
- Genomics
- ISSN
- 0888-7543
- eISSN
- 1089-8646
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 06/01/1998
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006451702771
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