Journal article
A Genetic Familial Study of Monoamine Oxidase B Activity and Concentration in Alcoholics
Alcoholism, clinical and experimental research, Vol.17(2), pp.263-267
Received for publication November 19, 1991; accepted October 8, 1992
04/1993
DOI: 10.1111/j.1530-0277.1993.tb00760.x
PMID: 8488965
Abstract
Platelet monoamine oxidase B (MAO B) activity and concentration were studied in a small sample of alcoholic families (n= 8) and in 20 unrelated, nonalcoholic controls. Complex segregation analyses of familial data indicated that both activity and concentration are controlled by a single major gene locus with a multifactorial background effect accounting for 0–50% of the variance. When the alcoholic family members (n= 24) were compared with the controls, all determinations of activity display significant differences, whereas MAO B concentration levels showed no difference. These results indicated that the lowered MAO B activities frequently reported among alcoholics do not reflect a change in the number of MAO B macromolecules expressed in platelets, but could be caused by the presence of an inhibitor or by a polymorphic or variant form of the enzyme.
Details
- Title: Subtitle
- A Genetic Familial Study of Monoamine Oxidase B Activity and Concentration in Alcoholics
- Creators
- Eric J Devor - University of Iowa, Obstetrics and GynecologyC. Robert Cloninger - Department of Psychiatry, Washington University School of Medicine, St. Louis, MissouriSau-Wah Kwan - the Division of Medicinal Chemistry, College of Pharmacy and Institute for Neuroscience, University of Texas, Austin, TexasCreed W Abell - the Division of Medicinal Chemistry, College of Pharmacy and Institute for Neuroscience, University of Texas, Austin, Texas
- Resource Type
- Journal article
- Publication Details
- Alcoholism, clinical and experimental research, Vol.17(2), pp.263-267
- Edition
- Received for publication November 19, 1991; accepted October 8, 1992
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1111/j.1530-0277.1993.tb00760.x
- PMID
- 8488965
- ISSN
- 0145-6008
- eISSN
- 1530-0277
- Number of pages
- 5
- Language
- English
- Date published
- 04/1993
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983557414602771
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