Journal article
A Hip Analysis Protocol for Pediatric Bone Densitometry: The Iowa Bone Development Study
Journal of Clinical Densitometry, Vol.13(4), pp.361-369
2010
DOI: 10.1016/j.jocd.2010.06.003
PMCID: PMC3401562
PMID: 20850364
Abstract
Pediatric proximal femur dual-energy X-ray absorptiometry (DXA) scans present analytic challenges because of the lack of standard points of reference in the growing skeleton. The Iowa Bone Development Study (IBDS) developed a modified pediatric-specific proximal femur analysis protocol using Hologic software. Serial DXA measurements were obtained for 214 children at approximate ages 5, 8, 11, and 13 yr. Standard analysis procedures as described by the manufacturer (Hologic default) were compared with the IBDS protocol. The IBDS protocol yielded lower but more stable results for bone area, bone mineral content (BMC), and bone mineral density for total hip, femoral neck, trochanter, and intertrochanter as a result of more precisely controlling the regions of interest. Linear regression models with body size, age, and gender as predictors were developed to examine variation in measurements. Coefficients of determination ( R 2) with the IBDS protocol were greater for each time point, demonstrating that the modified protocol was better aligned with body size. Similarly, Spearman correlation coefficients between total hip and hip subregions were consistently higher for BMC and bone area with the IBDS protocol with differences more notable among younger children. The IBDS protocol provides a reproducible method for evaluating pediatric proximal femur DXA scans during growth.
Details
- Title: Subtitle
- A Hip Analysis Protocol for Pediatric Bone Densitometry: The Iowa Bone Development Study
- Creators
- Julie M Eichenberger Gilmore - Department of Preventive and Community Dentistry, The University of Iowa, Iowa City, IA, USACynthia A Pauley - Department of Preventive and Community Dentistry, The University of Iowa, Iowa City, IA, USATrudy L Burns - Department of Epidemiology, The University of Iowa, Iowa City, IA, USAJames C Torner - Department of Epidemiology, The University of Iowa, Iowa City, IA, USAElena M Letuchy - Department of Epidemiology, The University of Iowa, Iowa City, IA, USAKathleen F Janz - Department of Epidemiology, The University of Iowa, Iowa City, IA, USAMarcia C Willing - Department of Pediatrics, The University of Iowa, Iowa City, IA, USASteven M Levy - Department of Preventive and Community Dentistry, The University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of Clinical Densitometry, Vol.13(4), pp.361-369
- DOI
- 10.1016/j.jocd.2010.06.003
- PMID
- 20850364
- PMCID
- PMC3401562
- NLM abbreviation
- J Clin Densitom
- ISSN
- 1094-6950
- eISSN
- 1559-0747
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2010
- Academic Unit
- Preventive and Community Dentistry; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery; Health, Sport, and Human Physiology
- Record Identifier
- 9983917781702771
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