Journal article
A Holistic Framework for the Evaluation of Kidney Function in a Gender-Diverse Landscape
American journal of kidney diseases, Vol.84(2), pp.232-240
08/2024
DOI: 10.1053/j.ajkd.2024.01.522
PMID: 38458377
Abstract
The most commonly used equations to estimate glomerular filtration rate incorporate a binary male-female sex coefficient, which has important implications for the care of transgender, gender-diverse, and non-binary (TGD) people. Whether "sex assigned at birth" or a binary "gender identity" is most appropriate for the computation of estimated glomerular filtration rate (eGFR) is unknown. Furthermore, the use of gender-affirming hormone therapy (GAHT) for the development of physical changes to align TGD people with their affirmed gender is increasingly common, and may result in changes in serum creatinine and cystatin C, biomarkers commonly used to estimate glomerular filtration rate. The paucity of current literature evaluating chronic kidney disease (CKD) prevalence and outcomes in TGD individuals on GAHT makes it difficult to assess any effects of GAHT on kidney function. Whether alterations in serum creatinine reflect changes in glomerular filtration rate or simply changes in muscle mass is unknown. Therefore, we propose a holistic framework to evaluate kidney function in TGD people. The framework focuses on kidney disease prevalence, risk factors, sex hormones, eGFR, other kidney function assessment tools, and the mitigation of health inequities in TGD people.
Details
- Title: Subtitle
- A Holistic Framework for the Evaluation of Kidney Function in a Gender-Diverse Landscape
- Creators
- Keila Turino Miranda - University of CalgaryDina N Greene - University of WashingtonDavid Collister - University of AlbertaMatthew D Krasowski - University of IowaSofia B Ahmed - University of CalgaryLauren R Cirrincione - University of WashingtonSylvia E Rosas - Joslin Diabetes CenterNathalie Saad - University of CalgaryChristina C Pierre - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- American journal of kidney diseases, Vol.84(2), pp.232-240
- DOI
- 10.1053/j.ajkd.2024.01.522
- PMID
- 38458377
- NLM abbreviation
- Am J Kidney Dis
- ISSN
- 0272-6386
- eISSN
- 1523-6838
- Language
- English
- Electronic publication date
- 03/06/2024
- Date published
- 08/2024
- Academic Unit
- Pathology
- Record Identifier
- 9984567869602771
Metrics
17 Record Views