A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease

Yujia Liu; Ronald A Merrill; Stefan Strack

doi:10.3390/cells9020298

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A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease

Journal article

Open access

Peer reviewed

A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease

Yujia Liu, Ronald A Merrill and Stefan Strack

Cells (Basel, Switzerland), Vol.9(2), p.298

02/01/2020

DOI: 10.3390/cells9020298

PMCID: PMC7072574

PMID: 31991888

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Abstract

Best known as the powerhouse of the cell, mitochondria have many other important functions such as buffering intracellular calcium and reactive oxygen species levels, initiating apoptosis and supporting cell proliferation and survival. Mitochondria are also dynamic organelles that are constantly undergoing fission and fusion to meet specific functional needs. These processes and functions are regulated by intracellular signaling at the mitochondria. A-kinase anchoring protein 1 (AKAP1) is a scaffold protein that recruits protein kinase A (PKA), other signaling proteins, as well as RNA to the outer mitochondrial membrane. Hence, AKAP1 can be considered a mitochondrial signaling hub. In this review, we discuss what is currently known about AKAP1′s function in health and diseases. We focus on the recent literature on AKAP1′s roles in metabolic homeostasis, cancer and cardiovascular and neurodegenerative diseases. In healthy tissues, AKAP1 has been shown to be important for driving mitochondrial respiration during exercise and for mitochondrial DNA replication and quality control. Several recent in vivo studies using AKAP1 knockout mice have elucidated the role of AKAP1 in supporting cardiovascular, lung and neuronal cell survival in the stressful post-ischemic environment. In addition, we discuss the unique involvement of AKAP1 in cancer tumor growth, metastasis and resistance to chemotherapy. Collectively, the data indicate that AKAP1 promotes cell survival throug regulating mitochondrial form and function. Lastly, we discuss the potential of targeting of AKAP1 for therapy of various disorders.

heart failure

PKA

neurodegeneration

metabolism

mitochondrial dysfunction

cancer

Review

mitochondrial fission

AKAP1

Drp1

Details

Title: Subtitle: A-Kinase Anchoring Protein 1: Emerging Roles in Regulating Mitochondrial Form and Function in Health and Disease
Creators: Yujia Liu - Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Ronald A Merrill - Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Stefan Strack - Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Cells (Basel, Switzerland), Vol.9(2), p.298
DOI: 10.3390/cells9020298
PMID: 31991888
PMCID: PMC7072574
NLM abbreviation: Cells
ISSN: 2073-4409
eISSN: 2073-4409
Publisher: MDPI
Grant note: DOI: 10.13039/100000009, name: National Institutes of Health, award: DK116624, MH115673, DK116624, MH115673
Language: English
Date published: 02/01/2020
Academic Unit: Molecular Physiology and Biophysics; Pathology; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
Record Identifier: 9984071694802771

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