Journal article
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
American journal of human genetics, Vol.102(3), pp.375-400
03/01/2018
DOI: 10.1016/j.ajhg.2018.01.015
PMID: 29455858
Abstract
Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined ∼18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 × 10−8) in stage 1 and formally replicated in stage 2. A combined stage 1 and 2 meta-analysis identified 66 additional genome-wide significant loci (13, 35, and 18 loci in European, African, and trans-ancestry, respectively). A total of 56 known BP loci were also identified by our results (p < 5 × 10−8). Of the newly identified loci, ten showed significant interaction with smoking status, but none of them were replicated in stage 2. Several loci were identified in African ancestry, highlighting the importance of genetic studies in diverse populations. The identified loci show strong evidence for regulatory features and support shared pathophysiology with cardiometabolic and addiction traits. They also highlight a role in BP regulation for biological candidates such as modulators of vascular structure and function (CDKN1B, BCAR1-CFDP1, PXDN, EEA1), ciliopathies (SDCCAG8, RPGRIP1L), telomere maintenance (TNKS, PINX1, AKTIP), and central dopaminergic signaling (MSRA, EBF2).
Details
- Title: Subtitle
- A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
- Creators
- Yun J Sung - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USAJennifer G Robinson - Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, USAThomas W Winkler - Department of Genetic Epidemiology, University of Regensburg, Regensburg 93051, GermanyJames Scott - National Heart and Lung Institute, Imperial College London, London W12 0NN, UKLisa de las Fuentes - Cardiovascular Division, Department of Medicine, Washington University, St. Louis, MO 63110, USAAmy R Bentley - Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USAMichael R Brown - Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USAAldi T Kraja - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USAKaren Schwander - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USAIoanna Ntalla - William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UKXiuqing Guo - Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USANora Franceschini - Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USAYingchang Lu - Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USAChing-Yu Cheng - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, SingaporeXueling Sim - Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, SingaporeDina Vojinovic - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsJonathan Marten - Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UKSolomon K Musani - Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USAChangwei Li - Department of Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, GA 30602, USAMary F Feitosa - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USATuomas O Kilpeläinen - Section of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, DenmarkMelissa A Richard - Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USARaymond Noordam - Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300RC, the NetherlandsStella Aslibekyan - Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USAHugues Aschard - Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USATraci M Bartz - Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA 98101, USARajkumar Dorajoo - Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, SingaporeAlisa K Manning - Center for Human Genetics Research, Massachusetts General Hospital, Boston, MA 02114, USATuomo Rankinen - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USAAlbert Vernon Smith - Icelandic Heart Association, Kopavogur 201, IcelandSalman M Tajuddin - Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USABamidele O Tayo - Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USAHelen R Warren - William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UKWei Zhao - School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USAYanhua Zhou - Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USANana Matoba - Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, JapanTamar Sofer - Department of Biostatistics, University of Washington, Seattle, WA 98105, USAMaris Alver - Estonian Genome Center, University of Tartu, Tartu 51010, EstoniaMarzyeh Amini - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the NetherlandsMathilde Boissel - CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, FranceJin Fang Chai - Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, SingaporeXu Chen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, SwedenJasmin Divers - Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USAIlaria Gandin - Department of Medical Sciences, University of Trieste, Trieste 34137, ItalyChuan Gao - Department of Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC 27157, USAFranco Giulianini - Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USAAnuj Goel - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UKSarah E Harris - Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UKFernando Pires Hartwig - Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, BrazilAndrea R.V.R Horimoto - Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, BrazilFang-Chi Hsu - Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USAAnne U Jackson - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USAMika Kähönen - Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, FinlandAnuradhani Kasturiratne - Department of Public Health, University of Kelaniya, Ragama, Sri LankaBrigitte Kühnel - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyKarin Leander - Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, SwedenWen-Jane Lee - Department of Medical Research, Taichung Veterans General Hospital, Department of Social Work, Tunghai University, Taichung 40705, TaiwanKeng-Hung Lin - Department of Opthalmology, Taichung Veterans General Hospital, Taichung 40705, TaiwanJian ’an Luan - MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UKColin A McKenzie - Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, JamaicaHe Meian - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, ChinaChristopher P Nelson - Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UKRainer Rauramaa - Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, FinlandNicole Schupf - Taub Institute for Research on Alzheimer disease and the Aging Brain, Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USARobert A Scott - MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UKWayne H.H Sheu - Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, TaiwanAlena Stančáková - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio 70210, FinlandFumihiko Takeuchi - Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, JapanPeter J van der Most - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the NetherlandsTibor V Varga - Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, SwedenHeming Wang - Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USAYajuan Wang - Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USAErin B Ware - School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USAStefan Weiss - Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz Arndt University Greifswald, Greifswald 17487, GermanyWanqing Wen - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USALisa R Yanek - General Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USAWeihua Zhang - Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UKSaima Afaq - Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UKTamuno Alfred - Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USANajaf Amin - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsDan Arking - McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USATin Aung - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, SingaporeR. Graham Barr - Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USALawrence F Bielak - School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USAEric Boerwinkle - Human Genetics Center, The University of Texas School of Public Health, Houston, TX 77030, USAErwin P Bottinger - Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USAPeter S Braund - Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UKJennifer A Brody - Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USAUlrich Broeckel - Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USAClaudia P Cabrera - William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UKBrian Cade - Sleep Medicine and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115, USAYu Caizheng - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, ChinaArchie Campbell - Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UKMickaël Canouil - CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, FranceAravinda Chakravarti - Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAGanesh Chauhan - Centre for Brain Research, Indian Institute of Schience, Bangalore 560012, IndiaKaare Christensen - The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, DenmarkMassimiliano Cocca - Department of Medical Sciences, University of Trieste, Trieste 34137, ItalyFrancis S Collins - Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USAJohn M Connell - Ninewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UKRenée de Mutsert - Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the NetherlandsStephanie Debette - Inserm U1219 Neuroepidemiology, University of Bordeaux, Bordeaux, FranceH. Janaka de Silva - Department of Medicine, University of Kelaniya, Ragama, Sri LankaMarcus Dörr - DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, GermanyQing Duan - Department of Genetics, University of North Carolina, Chapel Hill, NC 27514, USACharles B Eaton - Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI 02860, USAGeorg Ehret - Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAEvangelos Evangelou - Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UKJessica D Faul - Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USAVirginia A Fisher - Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USANita G Forouhi - MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UKOscar H Franco - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsYechiel Friedlander - Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem 91120, IsraelHe Gao - Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UKBruna Gigante - Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, SwedenMisa Graff - Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USAC. Charles Gu - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USADongfeng Gu - Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaSaskia P Hagenaars - Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UKTamara B Harris - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USAJiang He - Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USASami Heikkinen - University of Eastern Finland, Institute of Biomedicine, Kuopio 70211, FinlandChew-Kiat Heng - Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, SingaporeMakoto Hirata - Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku 108-8639, JapanAlbert Hofman - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsBarbara V Howard - MedStar Health Research Institute, Hyattsville, MD 20782, USASteven Hunt - Cardiovascular Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USAMarguerite R Irvin - Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USARoby Joehanes - Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USAAnne E Justice - Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USATomohiro Katsuya - Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita 5650871, JapanJoel Kaufman - Epidemiology, Department of Occupational and Environmental Medicine Program, University of Washington, Seattle, WA 98105, USANicola D Kerrison - MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UKChiea Chuen Khor - Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, SingaporeWoon-Puay Koh - Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, SingaporeHeikki A Koistinen - Department of Health, National Institute for Health and Welfare, Helsinki 00271, FinlandPirjo Komulainen - Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, FinlandCharles Kooperberg - Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USAJose E Krieger - Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, BrazilMichiaki Kubo - Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, JapanClaudia Langenberg - MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UKLenore J Launer - Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USAJohanna Kuusisto - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, FinlandBenjamin Lehne - Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UKCarl D Langefeld - Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USACora E Lewis - Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USAYize Li - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USASing Hui Lim - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, SingaporeShiow Lin - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USAChing-Ti Liu - Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USAJianjun Liu - Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, SingaporeJingmin Liu - WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USAKiang Liu - Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USAMarie Loh - Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UKKurt K Lohman - Division of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USAJirong Long - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USATin Louie - Department of Biostatistics, University of Washington, Seattle, WA 98105, USAReedik Mägi - Estonian Genome Center, University of Tartu, Tartu 51010, EstoniaAnubha Mahajan - Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UKThomas Meitinger - Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyAndres Metspalu - Estonian Genome Center, University of Tartu, Tartu 51010, EstoniaLili Milani - Estonian Genome Center, University of Tartu, Tartu 51010, EstoniaYukihide Momozawa - Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, JapanAndrew P Morris - Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UKThomas H Mosley - Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USAPeter Munson - Mathematical and Statistical Computing Laboratory, Center for Information Technology, NIH, Bethesda, MD 20892, USAAlison D Murray - The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen AB25 2ZD, UKMike A Nalls - Data Tecnica International, Glen Echo, MD 20812, USAUbaydah Nasri - Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USAJill M Norris - Department of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, USAKari North - Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USAAdesola Ogunniyi - Department of Medicine, University of Ibadan, Ibadan, NigeriaSandosh Padmanabhan - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UKWalter R Palmas - Internal Medicine, Department of Medicine, Columbia University, New York, NY 10032, USANicholette D Palmer - Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USAJames S Pankow - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USANancy L Pedersen - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, SwedenTreva K Rice - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USAAnnette Peters - Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyPaul M Ridker - Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USAPatricia A Peyser - School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USAOzren Polasek - Faculty of Medicine, University of Split, Split, CroatiaAntonietta Robino - Medical Genetics, IRCCS Burlo, Garofolo 34137, ItalyOlli T Raitakari - Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, FinlandFrida Renström - Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, SwedenIgor Rudan - Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UKCharumathi Sabanayagam - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, SingaporeBabatunde L Salako - Department of Medicine, University of Ibadan, Ibadan, NigeriaKevin Sandow - Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USACarsten O Schmidt - DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, GermanyPamela J Schreiner - Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USAWilliam R Scott - Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UKSudha Seshadri - Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USAPeter Sever - International Centre for Circulatory Health, Imperial College London, London W2 1PG, UKColleen M Sitlani - Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USAJennifer A Smith - School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USAHarold Snieder - Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the NetherlandsJohn M Starr - Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UKKonstantin Strauch - Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyHua Tang - Department of Genetics, Stanford University, Stanford, CA 94305, USAYik Ying Teo - Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, SingaporeYih Chung Tham - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, SingaporeAndré G Uitterlinden - Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the NetherlandsMelanie Waldenberger - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyKent D Taylor - Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USAYa X Wang - Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China 100730, ChinaChristine Williams - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USAGregory Wilson - Jackson Heart Study, Department of Public Health, Jackson State University, Jackson, MS 39213, USAMary K Wojczynski - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USAJie Yao - Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USAJian-Min Yuan - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USAAlan B Zonderman - Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USADiane M Becker - General Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USAMichael Boehnke - Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USADonald W Bowden - Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USAJohn C Chambers - Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UKYii-Der Ida Chen - Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USAUlf de Faire - Institute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, SwedenIan J Deary - Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UKTõnu Esko - Estonian Genome Center, University of Tartu, Tartu 51010, EstoniaTerrence Forrester - Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, JamaicaPaul W Franks - Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, SwedenBarry I Freedman - Division of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USAPhilippe Froguel - CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, FrancePaolo Gasparini - Department of Medical Sciences, University of Trieste, Trieste 34137, ItalyChristian Gieger - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyBernardo Lessa Horta - Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, BrazilMartin Farrall - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UKJost B Jonas - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaNorihiro Kato - Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, JapanJaspal S Kooner - Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UKMarkku Laakso - Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, FinlandTerho Lehtimäki - Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, FinlandKae-Woei Liang - School of Medicine, National Yang-ming University, Taipei, TaiwanPatrik K.E Magnusson - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, SwedenAnne B Newman - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USAAlbertine J Oldehinkel - Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the NetherlandsAlexandre C Pereira - Lab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, BrazilSusan Redline - Sleep Medicine and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA 02115, USARainer Rettig - DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, GermanyNilesh J Samani - Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UKXiao-Ou Shu - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USAPim van der Harst - Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the NetherlandsLynne E Wagenknecht - Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USANicholas J Wareham - MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UKHugh Watkins - Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UKDavid R Weir - Institute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USAAnanda R Wickremasinghe - Department of Public Health, University of Kelaniya, Ragama, Sri LankaTangchun Wu - Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, ChinaWei Zheng - Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USAYoichiro Kamatani - Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, JapanCathy C Laurie - Department of Biostatistics, University of Washington, Seattle, WA 98105, USAClaude Bouchard - Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USARichard S Cooper - Department of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USAMichele K Evans - Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USAVilmundur Gudnason - Icelandic Heart Association, Kopavogur 201, IcelandSharon L.R Kardia - School of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USAStephen B Kritchevsky - Sticht Center for Health Aging and Alzheimer’s Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADaniel Levy - Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USAJeff R O’Connell - Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USABruce M Psaty - Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA 98101, USARob M van Dam - Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, SingaporeMario Sims - Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USADonna K Arnett - Dean’s Office, University of Kentucky College of Public Health, Lexington, KY 40536, USADennis O Mook-Kanamori - Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the NetherlandsTanika N Kelly - Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USAErvin R Fox - Cardiology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USACaroline Hayward - Medical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UKMyriam Fornage - Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USACharles N Rotimi - Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USAMichael A Province - Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USACornelia M van Duijn - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the NetherlandsE. Shyong Tai - Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, SingaporeTien Yin Wong - Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, SingaporeRuth J.F Loos - Icahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USAAlex P Reiner - Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USAJerome I Rotter - Genomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USAXiaofeng Zhu - Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USALaura J Bierut - Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USAW. James Gauderman - University of California, Los AngelesMark J Caulfield - William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UKPaul Elliott - Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UKKenneth Rice - Department of Biostatistics, University of Washington, Seattle, WA 98105, USAPatricia B Munroe - William Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UKAlanna C Morrison - Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USAL. Adrienne Cupples - Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USADabeeru C Rao - Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USADaniel I Chasman - Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USAThe CHARGE Neurology Working GroupPreeti GuptaYongmei Liu - Wake Forest UniversityYi-Jen Hung - National Defense Medical CenterLynda M RoseWen Bin Wei - Capital Medical UniversityLihua Wang - Washington University in St. LouisYucheng Jia - University of California, Los AngelesJing Hua Zhao - University of CambridgeYeheng Liu - University of California, Los Angeles
- Resource Type
- Journal article
- Publication Details
- American journal of human genetics, Vol.102(3), pp.375-400
- DOI
- 10.1016/j.ajhg.2018.01.015
- PMID
- 29455858
- NLM abbreviation
- Am J Hum Genet
- ISSN
- 0002-9297
- eISSN
- 1537-6605
- Publisher
- Elsevier Inc
- Grant note
- name: U.S. National Heart, Lung, and Blood Institute (NHLBI), the National Institutes of Health, award: R01HL118305, K25HL121091; DOI: 10.13039/100000050, name: NHLBI
- Language
- English
- Date published
- 03/01/2018
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995176802771
Metrics
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