Journal article
A Mammalian H + Channel Generated Through Alternative Splicing of the NADPH Oxidase Homolog NOH-1
Science (American Association for the Advancement of Science), Vol.287(5450), pp.138-142
01/07/2000
DOI: 10.1126/science.287.5450.138
PMID: 10615049
Abstract
Voltage-gated proton (H+) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191–amino acid protein is described that, upon heterologous expression, has properties indistinguishable from those of native H+ channels. This protein is generated through alternative splicing of messenger RNA derived from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate).
Details
- Title: Subtitle
- A Mammalian H + Channel Generated Through Alternative Splicing of the NADPH Oxidase Homolog NOH-1
- Creators
- Botond Bánfi - University of Iowa, OtolaryngologyAndrés Maturana - University of GenevaStefano JaconiSerge Arnaudeau - University Hospital of GenevaTerese LaforgeBhanu Sinha - Division of Infectious Diseases, Geneva University Hospitals, Geneva Medical School, CH-1211 Geneva 4, SwitzerlandErzsébet Ligeti - Semmelweis UniversityNicolas Demaurex - University of GenevaKarl-Heinz Krause - University Hospital of Geneva
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.287(5450), pp.138-142
- DOI
- 10.1126/science.287.5450.138
- PMID
- 10615049
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 01/07/2000
- Academic Unit
- Anatomy and Cell Biology; Otolaryngology; Internal Medicine
- Record Identifier
- 9984284449902771
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