Journal article
A Mild and Highly Diastereoselective Preparation of N-Alkenyl-2-Pyridones via 2-Halopyridinium Salts and Aldehydes
Journal of organic chemistry, Vol.86(18), pp.13134-13142
09/17/2021
DOI: 10.1021/acs.joc.1c01566
PMCID: PMC8453634
PMID: 34464531
Appears in UI Libraries Support Open Access
Abstract
An experimentally simple one-pot preparation of N-alkenyl-2-pyridones is reported. The reaction features mild conditions using readily available 2-halopyridinium salts and aldehydes. N-Alkenyl-2-pyridone formation proceeds with high diastereoselectivity, and a wide range of aldehyde reaction partners is tolerated. Pyridone products are also amenable to further manipulation, including conversion to N-alkyl pyridones and polycyclic ring systems.
Details
- Title: Subtitle
- A Mild and Highly Diastereoselective Preparation of N-Alkenyl-2-Pyridones via 2-Halopyridinium Salts and Aldehydes
- Creators
- Grant N Shivers - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United StatesF. Christopher Pigge - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States
- Resource Type
- Journal article
- Publication Details
- Journal of organic chemistry, Vol.86(18), pp.13134-13142
- DOI
- 10.1021/acs.joc.1c01566
- PMID
- 34464531
- PMCID
- PMC8453634
- NLM abbreviation
- J Org Chem
- ISSN
- 0022-3263
- eISSN
- 1520-6904
- Publisher
- American Chemical Society
- Language
- English
- Date published
- 09/17/2021
- Academic Unit
- Radiology; Chemistry
- Record Identifier
- 9984216682702771
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