Journal article
A Molecular Component of the Arterial Baroreceptor Mechanotransducer
Neuron (Cambridge, Mass.), Vol.21(6), pp.1435-1441
1998
DOI: 10.1016/S0896-6273(00)80661-3
PMID: 9883735
Abstract
Baroreceptor nerve endings detect acute fluctuations in arterial pressure. We tested the hypothesis that members of the DEG/ENaC family of cation channels, which are responsible for touch sensation in
Caenorhabditis elegans, may be components of the baroreceptor mechanosensor. We found the γ subunit of ENaC localized to the site of mechanotransduction in baroreceptor nerve terminals innervating the aortic arch and carotid sinus. A functional role for DEG/ENaC members was suggested by blockade of baroreceptor nerve activity and baroreflex control of blood pressure by an amiloride analog that inhibits DEG/ENaC channels. These data suggest that ENaC subunits may be components of the baroreceptor mechanotransducer and pave the way to a better definition of mechanisms responsible for blood pressure regulation and hypertension.
Details
- Title: Subtitle
- A Molecular Component of the Arterial Baroreceptor Mechanotransducer
- Creators
- Heather A Drummond - Departments of Internal Medicine and Physiology and Biophysics and, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242, USAMargaret P Price - Departments of Internal Medicine and Physiology and Biophysics and, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242, USAMichael J Welsh - Departments of Internal Medicine and Physiology and Biophysics and, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242, USAFrancois M Abboud - Departments of Internal Medicine and Physiology and Biophysics and, Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.21(6), pp.1435-1441
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0896-6273(00)80661-3
- PMID
- 9883735
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 1998
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984020897602771
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