A Multicenter Study of Bacterial Vaginosis in Women With or at Risk for Human Immunodeficiency Virus Infection

Dora Warren; Robert S. Klein; Jack Sobel; Burney Kieke; William Brown; Paula Schuman; Jean Anderson; Susan Cu-Uvin; Kenneth Mayer; Denise J. Jamieson; Scott Holmberg; Ann Duerr; HIV Epidemiology Research Study Group

doi:10.1155/S1064744901000242

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A Multicenter Study of Bacterial Vaginosis in Women With or at Risk for Human Immunodeficiency Virus Infection

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A Multicenter Study of Bacterial Vaginosis in Women With or at Risk for Human Immunodeficiency Virus Infection

Dora Warren, Robert S. Klein, Jack Sobel, Burney Kieke, William Brown, Paula Schuman, Jean Anderson, Susan Cu-Uvin, Kenneth Mayer, Denise J. Jamieson, …

Infectious diseases in obstetrics and gynecology, Vol.9(3), pp.133-141

2001

DOI: 10.1155/S1064744901000242

PMCID: PMC1784649

PMID: 11516061

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Abstract

Background: Bacterial vaginosis is a common gynecologic infection that has been associated with a variety of gynecologic and obstetric complications, including pelvic inflammatory disease, postabortal infection and premature delivery. Recent studies suggest that bacterial vaginosis may increase a woman’s risk for human immunodeficiency virus (HIV). We undertook this study to assess whether the prevalence and characteristics of bacterial vaginosis differed according to HIV status in high-risk US women. Methods: Prevalence of bacterial vaginosis was assessed by Gram’s stain and clinical criteria for 854 HIV-infected and 434 HIV-uninfected women enrolled in the HIV Epidemiology Research (HER) Study.Multiple logistic regression techniques were used to determine whether HIV infection independently predicted bacterial vaginosis. Results: Almost half (46%) the women had bacterial vaginosis by Gram’s stain. The prevalence of bacterial vaginosis was 47% in the HIV-positive women compared with 44% in the HIV-negativewomen; this difference was not statistically significant (p = 0.36). After adjustment for other covariates, HIV-positive women were more likely than HIV-negative women to have bacterial vaginosis (odds ratio (OR) 1.31; 95% confidence interval (CI) 1.01-1.70) by Gram's stain but not by clinical criteria (OR 1.16; CI 0.87-1.55). Among HIV-positive women, use of antiretroviral drugs was associated with a lower prevalence of bacterial vaginosis (adjusted OR 0.54; Cl 0.38 -0.77). Conclusions: In this cross-sectional analysis of high-risk US women, HIV infection was positively correlated with bacterial vaginosis diagnosed by Gram’s stain.

Details

Title: Subtitle: A Multicenter Study of Bacterial Vaginosis in Women With or at Risk for Human Immunodeficiency Virus Infection
Creators: Dora Warren
Robert S. Klein - Albert Einstein College of Medicine
Jack Sobel - Wayne State University
Burney Kieke
William Brown - Wayne State University
Paula Schuman - Wayne State University
Jean Anderson
Susan Cu-Uvin - Miriam Hospital
Kenneth Mayer - Miriam Hospital
Denise J. Jamieson
Scott Holmberg
Ann Duerr
HIV Epidemiology Research Study Group
Resource Type: Journal article
Publication Details: Infectious diseases in obstetrics and gynecology, Vol.9(3), pp.133-141
DOI: 10.1155/S1064744901000242
PMID: 11516061
PMCID: PMC1784649
NLM abbreviation: Infect Dis Obstet Gynecol
ISSN: 1064-7449
eISSN: 1098-0997
Publisher: Hindawi Publishing Corporation
Language: English
Date published: 2001
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446555802771

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