Journal article
A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome
Journal of clinical neurophysiology, Vol.42(3), pp.230-234
03/2025
DOI: 10.1097/WNP.0000000000001101
PMCID: PMC11864053
PMID: 40009427
Abstract
Purpose: The best possible outcomes in infantile epileptic spasms syndrome require electroclinical remission; however, determining electrographic remission is not straightforward. Although the determination of hypsarrhythmia has inadequate interrater reliability (IRR), the Burden of AmplitudeS and Epileptiform Discharges (BASED) score has shown promise for the reliable interictal assessment of infantile epileptic spasms syndrome. Our aim was to develop a BASED training program and assess the IRR among learners. We hypothesized moderate or better IRR for the final BASED score and the presence or absence of epileptic encephalopathy (+/−EE). Methods: Using a web-based application, 31 learners assessed 12 unmarked EEGs (length 1–6 hours) from children with infantile epileptic spasms syndrome. Results: For all readers, the IRR was good for the final BASED score (intraclass correlation coefficient 0.86) and +/−EE (Marginal Multirater Kappa 0.63). For all readers, the IRR was fair to good for all individual BASED score elements. Conclusions: These findings support the use of our training program to quickly learn the BASED scoring method. The BASED score may be a valuable clinical and research tool. Given that the IRR for the determination of epileptic encephalopathy is not perfect, clinical acumen remains paramount. Additional experience with the BASED scoring technique among learners and advances in collaborative EEG evaluation platforms may improve IRR.
Details
- Title: Subtitle
- A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome
- Creators
- John R. Mytinger - Nationwide Children's HospitalDara V. F. Albert - Nationwide Children's HospitalShawn C. Aylward - Nationwide Children's HospitalChristopher W. Beatty - Nationwide Children's HospitalSonam Bhalla - Emory UniversitySonal Bhatia - Medical University of South CarolinaGuy N. Brock - Nationwide Children's HospitalMicheal A. Ciliberto - University of Iowa, Neurology (Pediatrics)Purva R. Choudhari - The University of Texas Southwestern Medical CenterDaniel J. Clark - Nationwide Children's HospitalJennifer Madan Cohen - Connecticut Children's Medical CenterTheresa M. Czech - University of IowaMegan M. Fredwall - Nationwide Children's HospitalErnesto Gonzalez-Giraldo - University of California, San FranciscoChellamani Harini - Harvard UniversitySenyene E. Hunter - University of North Carolina HospitalsAmanda G. Sandoval Karamian - University of UtahAkshat Katyayan - Texas Children's HospitalIsaac Kistler - The Ohio State University Wexner Medical CenterNeil Kulkarni - Nationwide Children's HospitalVirginia B. Liu - Children's Hospital of Orange CountyCorinne McCabe - Nationwide Children's HospitalThomas Murray - Nationwide Children's HospitalKerri Neville - University of MichiganShital H. Patel - Duke Medical CenterSpriha Pavuluri - Children's Hospital & Medical CenterDonald J. Phillips - Children's Hospital of Orange CountyDebopam Samanta - University of Arkansas for Medical SciencesDeepa Sirsi - The University of Texas Southwestern Medical CenterEmily M. Spelbrink - Lucile Packard Children's HospitalCarl E. Stafstrom - Johns Hopkins MedicineMaija Steenari - Children's Hospital of Orange CountyDanielle S. Takacs - Texas Children's HospitalTyler Terrill - The University of Texas Southwestern Medical CenterLinh Tran - Cook Children's Medical CenterJorge Vidaurre - Nationwide Children's HospitalDaniel W. Shrey - University of California, Irvine
- Resource Type
- Journal article
- Publication Details
- Journal of clinical neurophysiology, Vol.42(3), pp.230-234
- DOI
- 10.1097/WNP.0000000000001101
- PMID
- 40009427
- PMCID
- PMC11864053
- NLM abbreviation
- J Clin Neurophysiol
- ISSN
- 0736-0258
- eISSN
- 1537-1603
- Language
- English
- Electronic publication date
- 07/11/2024
- Date published
- 03/2025
- Academic Unit
- Neurology; Stead Family Department of Pediatrics; Neurology (Pediatrics)
- Record Identifier
- 9984695682702771
Metrics
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