A Near Infra-Red Study of Blood Oxygenation Changes Resulting From High and Low Frequency Repetitive Transcranial Magnetic Stimulation

Ting T. Cao; Richard H. Thomson; Neil W. Bailey; Nigel C. Rogasch; Rebecca A. Segrave; Jerome J. Maller; Zafiris J. Daskalakis; Paul B. Fitzgerald

doi:10.1016/j.brs.2013.04.006

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A Near Infra-Red Study of Blood Oxygenation Changes Resulting From High and Low Frequency Repetitive Transcranial Magnetic Stimulation

Journal article

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A Near Infra-Red Study of Blood Oxygenation Changes Resulting From High and Low Frequency Repetitive Transcranial Magnetic Stimulation

Ting T. Cao, Richard H. Thomson, Neil W. Bailey, Nigel C. Rogasch, Rebecca A. Segrave, Jerome J. Maller, Zafiris J. Daskalakis and Paul B. Fitzgerald

Brain stimulation, Vol.6(6), pp.922-924

11/01/2013

DOI: 10.1016/j.brs.2013.04.006

PMID: 23721908

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https://doaj.org/article/2c27fb0d8d8348aea917f909eaef2a98View

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Abstract

High and low frequency repetitive transcranial magnetic stimulation (rTMS) are both used to treat major depressive disorder(MDD). However, the physiological mechanisms underlying the therapeutic benefit and the effect of the stimulation frequency are unclear. Twelve healthy participants received 1Hz, 2Hz, and 5Hz active rTMS. Twenty 5 second trains were delivered at left dorsolateral prefrontal cortex at 110% of resting motor threshold with a 25 second inter-train interval. Blood oxygenation (HbO) was significantly reduced following the 1Hz trains compared to the HbO increases observed in both the 2Hz and 5Hz conditions. There was no significant inter-hemispheric difference in response. These results suggest that short trains of high and low frequency rTMS delivered to prefrontal cortex evoke a differential HbO response and provide additional evidence that high frequency trains result in increased neural activity. The findings may provide further explanation for the improved symptoms observed in MDD patients treated with high frequency rTMS. (C) 2013 Elsevier Inc. All rights reserved.

Clinical Neurology

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Science & Technology

Details

Title: Subtitle: A Near Infra-Red Study of Blood Oxygenation Changes Resulting From High and Low Frequency Repetitive Transcranial Magnetic Stimulation
Creators: Ting T. Cao - Monash Alfred Psychiatry Research centre
Richard H. Thomson - Monash University
Neil W. Bailey - Monash Alfred Psychiatry Research centre
Nigel C. Rogasch - Monash Alfred Psychiatry Research centre
Rebecca A. Segrave - Monash Alfred Psychiatry Research centre
Jerome J. Maller - Monash Alfred Psychiatry Research centre
Zafiris J. Daskalakis - Centre for Addiction and Mental Health
Paul B. Fitzgerald - Monash University
Resource Type: Journal article
Publication Details: Brain stimulation, Vol.6(6), pp.922-924
DOI: 10.1016/j.brs.2013.04.006
PMID: 23721908
NLM abbreviation: Brain Stimul
ISSN: 1935-861X
eISSN: 1876-4754
Publisher: Elsevier
Number of pages: 3
Grant note: Brain and Behaviour Research Foundation Grant Family through the Centre for Addiction and Mental Health (CAMH) Foundation 178/05 / Australian Research Council (ARC); Australian Research Council Canadian Institutes of Health Research (CIHR) Temerty Family through the Centre for Addiction and Mental Health (CAMH) Foundation Ontario Mental Health Foundation (OMHF) National Health and Medical Research Council (NHMRC) Practitioner Fellowship; National Health & Medical Research Council (NHMRC) of Australia
Language: English
Date published: 11/01/2013
Academic Unit: Radiology
Record Identifier: 9984848505102771

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