A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

Hang-Nga Mai; Do-Yeon Kim; Dong Choon Hyun; Ju Hayng Park; Sang Min Lee; Du-Hyeong Lee

doi:10.3390/jcm8111831

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A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

Journal article

Open access

Peer reviewed

A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations

Hang-Nga Mai, Do-Yeon Kim, Dong Choon Hyun, Ju Hayng Park, Sang Min Lee and Du-Hyeong Lee

Journal of clinical medicine, Vol.8(11), p.1831

11/01/2019

DOI: 10.3390/jcm8111831

PMCID: PMC6912282

PMID: 31683956

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Abstract

Chlorhexidine (CHX) has been incorporated into the composition of polymethyl methacrylate (PMMA) dental restorations to enhance their antimicrobial performance. However, the controlled delivery of CHX remains a challenge. Although previous findings with pure silica or polymer coatings demonstrated the resistance to bacterial adhesion, they did not provide antibacterial activity beyond the coated surface. Polydimethylsiloxane (PDMS) and mesoporous silica nanoparticles (MSNs) are widely used in biomedical science as a transfer medium in drug delivery systems. Here, the MSNs are used to encapsulate CHX, and the combination is added to PDMS. A thin coating film is formed on the PMMA, using oxygen plasma and thermal treatment. The liquid chromatography analysis shows that the coating film has high encapsulation efficiency and loading capacity, with a slow and stable release rate of CHX. The cytotoxicity tests also show that the coating does not affect the proinflammatory cytokines, cellular mitotic activity, or apoptotic cell death. The ability of the coating to release CHX indicates that the coating may even be effective against bacteria that are not directly in contact with the surface. This antibacterial protective film is expected to be a novel method to inhibit bacterial activity distal to the coated surfaces of PMMA restorations.

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Science & Technology

Details

Title: Subtitle: A New Antibacterial Agent-Releasing Polydimethylsiloxane Coating for Polymethyl Methacrylate Dental Restorations
Creators: Hang-Nga Mai - Kyungpook Natl Univ, Sch Dent, Inst Translat Res Dent, Dept Prosthodont, Daegu 41940, South Korea
Do-Yeon Kim - Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea
Dong Choon Hyun - Kyungpook National University
Ju Hayng Park - Kyungpook National University
Sang Min Lee - Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea
Du-Hyeong Lee - Kyungpook Natl Univ, Sch Dent, Inst Translat Res Dent, Dept Prosthodont, Daegu 41940, South Korea
Resource Type: Journal article
Publication Details: Journal of clinical medicine, Vol.8(11), p.1831
DOI: 10.3390/jcm8111831
PMID: 31683956
PMCID: PMC6912282
NLM abbreviation: J Clin Med
ISSN: 2077-0383
eISSN: 2077-0383
Publisher: Mdpi
Number of pages: 14
Grant note: 2017R1C1B2004976 / National Research Foundation of Korea
Language: English
Date published: 11/01/2019
Academic Unit: Prosthodontics
Record Identifier: 9984914013302771

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