Journal article
A New Strategy for the Synthesis of Polychlorinated Biphenyl Metabolites
Chemical research in toxicology, Vol.8(1), pp.92-95
01/01/1995
DOI: 10.1021/tx00043a012
PMID: 7703372
Abstract
A general and high-yielding synthetic route is presented by which a variety of chlorinated dihydroxybiphenyl metabolites may be synthesized. These synthetic standards will permit the investigation of novel pathways of polychlorinated biphenyl activation. The biphenyldiols were synthesized via palladium-catalyzed cross-coupling of dimethoxyphenylboronic acids with aryl bromides in the presence of a base. The formed dimethoxybiphenyls were demethylated using boron tribromide to yield the chlorinated dihydroxybiphenyls. These compounds were characterized by IR, NMR, and GC/MS.
Details
- Title: Subtitle
- A New Strategy for the Synthesis of Polychlorinated Biphenyl Metabolites
- Creators
- Udo BauerAnthony R AmaroLarry W Robertson
- Resource Type
- Journal article
- Publication Details
- Chemical research in toxicology, Vol.8(1), pp.92-95
- Publisher
- American Chemical Society
- DOI
- 10.1021/tx00043a012
- PMID
- 7703372
- ISSN
- 0893-228X
- eISSN
- 1520-5010
- Language
- English
- Date published
- 01/01/1995
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984002590902771
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