Journal article
A New View into the Regulation of Purine Metabolism: The Purinosome
Trends in biochemical sciences, Vol.42(2), pp.141-154
02/01/2017
DOI: 10.1016/j.tibs.2016.09.009
PMCID: PMC5272809
PMID: 28029518
Abstract
Other than serving as building blocks for DNA and RNA, purine metabolites provide a cell with the necessary energy and cofactors to promote cell survival and proliferation. A renewed interest in how purine metabolism may fuel cancer progression has uncovered a new perspective into how a cell regulates purine need. Under cellular conditions of high purine demand, the de novo purine biosynthetic enzymes cluster near mitochondria and microtubules to form dynamic multienzyme complexes referred to as 'purinosomes'. In this review, we highlight the purinosome as a novel level of metabolic organization of enzymes in cells, its consequences for regulation of purine metabolism, and the extent that purine metabolism is being targeted for the treatment of cancers.
Details
- Title: Subtitle
- A New View into the Regulation of Purine Metabolism: The Purinosome
- Creators
- Anthony M. Pedley - Pennsylvania State UniversityStephen J. Benkovic - Pennsylvania State University
- Resource Type
- Journal article
- Publication Details
- Trends in biochemical sciences, Vol.42(2), pp.141-154
- DOI
- 10.1016/j.tibs.2016.09.009
- PMID
- 28029518
- PMCID
- PMC5272809
- NLM abbreviation
- Trends Biochem Sci
- ISSN
- 0968-0004
- eISSN
- 1362-4326
- Publisher
- Elsevier
- Number of pages
- 14
- Grant note
- NIH GM024129 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01GM024129 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 02/01/2017
- Academic Unit
- Biochemistry and Molecular Biology
- Record Identifier
- 9984771644702771
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