Journal article
A Non-Canonical Role for β-Secretase in the Retina
Advances in experimental medicine and biology, Vol.854, pp.333-339
01/01/2016
DOI: 10.1007/978-3-319-17121-0_44
PMID: 26427429
Abstract
It has long been established that β-Secretase (BACE) plays a critical role in the formation of amyloid plaques in Alzheimer's Disease patients, but it is only recently that the importance of β-secretases in retinal pathophysiology has been recognized. BACE expression is elevated in response to stress, and downregulation results in lysosomal abnormalities and mitochondrial changes. Inhibition of BACE can lead to reduced retinal function, retinal thinning, lipofuscin accumulation and vascular dysfunction in mice. Furthermore, BACE inhibition accelerates choroidal neovascularization (CNV) in mice. We propose that BACE plays an important role in retinal homeostasis and that BACE upregulation in response to stress is a protective measure.
Details
- Title: Subtitle
- A Non-Canonical Role for β-Secretase in the Retina
- Creators
- Qingwen Qian - Indiana University – Purdue University IndianapolisSayak K Mitter - Indiana University – Purdue University IndianapolisS Louise Pay - Indiana UniversityXiaoping Qi - Indiana University – Purdue University IndianapolisCatherine Bowes Rickman - Duke UniversityMaria B Grant - Indiana University – Purdue University IndianapolisMichael E Boulton - Indiana University – Purdue University Indianapolis
- Resource Type
- Journal article
- Publication Details
- Advances in experimental medicine and biology, Vol.854, pp.333-339
- DOI
- 10.1007/978-3-319-17121-0_44
- PMID
- 26427429
- eISBN
- 9783319171210; 3319171216
- ISSN
- 0065-2598
- eISSN
- 2214-8019
- Grant note
- EY019688 / NEI NIH HHS EY018358 / NEI NIH HHS EY019038 / NEI NIH HHS
- Language
- English
- Date published
- 01/01/2016
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984420925102771
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