Journal article
A Novel Method for Chronic Social Defeat Stress in Female Mice
Neuropsychopharmacology (New York, N.Y.), Vol.43(6), pp.1276-1283
05/01/2018
DOI: 10.1038/npp.2017.259
PMCID: PMC5916350
PMID: 29090682
Abstract
Historically, preclinical stress studies have often omitted , female subjects, despite evidence that women have higher rates of anxiety and depression. In rodents, many stress susceptibility and resilience studies have focused on males as one commonly used paradigm-chronic social defeat stress-has proven challenging to implement in females. We report a new version of the social defeat paradigm that works in female mice. By applying male odorants to females to increase resident male aggressive behavior, we find that female mice undergo repeated social defeat stress and develop social avoidance, decreased sucrose preference, and decreased time in the open arms of the elevated plus maze relative to control mice. Moreover, a subset of the female mice in this paradigm display resilience, maintaining control levels of social exploration and sucrose preference. This method produces comparable results to those obtained in male mice and will greatly facilitate studying female stress susceptibility.
Details
- Title: Subtitle
- A Novel Method for Chronic Social Defeat Stress in Female Mice
- Creators
- Alexander Z. Harris - Columbia UniversityPiray Atsak - Columbia UniversityZachary H. Bretton - Columbia UniversityEmma S. Holt - Columbia UniversityRaisa Alam - Columbia UniversityMitchell P. Morton - Columbia UniversityAtheir I. Abbas - Columbia UniversityE. David Leonardo - Columbia UniversityScott S. Bolkan - Columbia UniversityRene Hen - New York Psychoanalytic Society and InstituteJoshua A. Gordon - Columbia University
- Resource Type
- Journal article
- Publication Details
- Neuropsychopharmacology (New York, N.Y.), Vol.43(6), pp.1276-1283
- DOI
- 10.1038/npp.2017.259
- PMID
- 29090682
- PMCID
- PMC5916350
- NLM abbreviation
- Neuropsychopharmacology
- ISSN
- 0893-133X
- eISSN
- 1740-634X
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- Hope for Depression Research Foundation R01MH081968 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01 MH081968 / EDL K08 MH109735 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Language
- English
- Date published
- 05/01/2018
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984944740802771
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