A Novel Nano-Synthetic Hydrophilic Bone Graft (OsteoFlo HydroFiber) Is a Non-inferior Alternative to Iliac Crest Autograft in a Rabbit Posterolateral Fusion Model

Aaron M Blom; Emily B Petersen; Reagan A Grieser-Yoder; Catherine R Olinger; Douglas C Fredericks

doi:10.1177/21925682261442308

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A Novel Nano-Synthetic Hydrophilic Bone Graft (OsteoFlo HydroFiber) Is a Non-inferior Alternative to Iliac Crest Autograft in a Rabbit Posterolateral Fusion Model

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A Novel Nano-Synthetic Hydrophilic Bone Graft (OsteoFlo HydroFiber) Is a Non-inferior Alternative to Iliac Crest Autograft in a Rabbit Posterolateral Fusion Model

Aaron M Blom, Emily B Petersen, Reagan A Grieser-Yoder, Catherine R Olinger and Douglas C Fredericks

Global spine journal

04/20/2026

DOI: 10.1177/21925682261442308

PMID: 42003666

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Abstract

Study DesignExperimental.ObjectivesThe objective of the study was to evaluate the in vivo performance of SurGenTec OsteoFlo HydroFiber (OF-HF) (test material), compared to autograft (ICBG) in an established posterolateral spine fusion rabbit model. The test material was evaluated as a stand-alone and extender product with autograft (1:1).MethodsSixty-nine skeletally mature male New Zealand white rabbits underwent a single-level bilateral posterolateral intertransverse process spinal fusion at the L5-L6 level. Animals were randomly assigned to one of three groups: ICBG, ICBG + OF-HF, or OF-HF. Outcomes were assessed at 4 (N = 5/group), 8 (N = 8/group), and 12 weeks (N = 10/group) evaluating for spine fusion rate, new bone formation, graft resorption, and inflammatory response using radiographic, microCT, biomechanical, and histological endpoints.ResultsIn general, all animals appeared to be in good health both at the start and conclusion of the study. All previously mentioned fusion assessment methods at 12 weeks demonstrated a 60% fusion rate for the ICBG and OF-HF groups, while the ICBG + OF-HF group demonstrated a 50% fusion rate. MicroCT morphometric analysis showed the OF-HF groups to have a significantly greater bone volume ( < 0.05) at 12 weeks compared to the ICBG group.ConclusionsThe comparable fusion rates, combined with the significantly increased bone volume in both groups containing OF-HF at the 12-week interval demonstrates the OF-HF graft to be a non-inferior alternative to ICBG for stand-alone use or as an autograft extender.

Details

Title: Subtitle: A Novel Nano-Synthetic Hydrophilic Bone Graft (OsteoFlo HydroFiber) Is a Non-inferior Alternative to Iliac Crest Autograft in a Rabbit Posterolateral Fusion Model
Creators: Aaron M Blom - University of Iowa
Emily B Petersen - University of Iowa
Reagan A Grieser-Yoder - University of Iowa, Orthopedics and Rehabilitation
Catherine R Olinger - University of Iowa, Orthopedics and Rehabilitation
Douglas C Fredericks - University of Iowa
Resource Type: Journal article
Publication Details: Global spine journal
DOI: 10.1177/21925682261442308
PMID: 42003666
ISSN: 2192-5682
eISSN: 2192-5690
Publisher: Sage
Grant note: SurGenTec
The authors have no conflicts of interest related to this study and are not receiving payment nor own portion of the company manufacturing this material. This study was funded by SurGenTec.
Language: English
Electronic publication date: 04/20/2026
Academic Unit: Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Neurosurgery
Record Identifier: 9985154561302771

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