Journal article
A Novel Propofol Dosing Regimen for Pediatric Sedation during Radiologic Tests
Journal of clinical medicine, Vol.11(17), p.5076
08/29/2022
DOI: 10.3390/jcm11175076
PMCID: PMC9457389
PMID: 36079005
Abstract
The dose of propofol for pediatric sedation during radiologic tests has been proposed as an equation of 0.75 + 0.14 x age (months) + 45.82 x body surface area (m(2)) based on results in a previous study. We compared this equation and the conventional dosing strategy for sedation in children undergoing radiologic tests. An amount of 180 children scheduled for magnetic resonance imaging (MRI) were randomized to experimental and control groups. The initial induction dose of propofol calculated using the equation was administered in the experimental group. In the control group, children received 1 mg/kg of the initial induction dose of propofol. Then, 0.5 mg/kg of the additional dose was followed to induce sedation in both groups. When awake or moving, a rescue injection of 0.5 mg/kg propofol was given. The total induction dose was more significant in the experimental group. The number of injections for induction in the experimental group was lesser. The dose and number of rescue injections in the experimental group were significantly less. The equation for the induction dose of propofol in a previous study could achieve quick induction of sedation and prevent a rescue injection during sedation. However, caution is needed when using the equation.
Details
- Title: Subtitle
- A Novel Propofol Dosing Regimen for Pediatric Sedation during Radiologic Tests
- Creators
- Ji-Young Min - Catholic University of KoreaJeong-Rim Lee - Yonsei UniversityHye-Mi Lee - Yongin Severance Hosp, Anesthesia & Pain Res Inst, Dept Anesthesiol & Pain Med, 363 Dongbaekjukjeon Daero, Yongin 16995, South KoreaHo-Jae Nam - Yonsei UniversityHyo-Jin Byon - Yonsei University
- Resource Type
- Journal article
- Publication Details
- Journal of clinical medicine, Vol.11(17), p.5076
- DOI
- 10.3390/jcm11175076
- PMID
- 36079005
- PMCID
- PMC9457389
- NLM abbreviation
- J Clin Med
- ISSN
- 2077-0383
- eISSN
- 2077-0383
- Publisher
- Mdpi
- Number of pages
- 8
- Grant note
- HI16C0793 / Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea
- Language
- English
- Date published
- 08/29/2022
- Academic Unit
- Anesthesia
- Record Identifier
- 9984806507802771
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