A Numerical Study of Water Loss Rate Distributions in MDCT-Based Human Airway Models

Dan Wu; Shinjiro Miyawaki; Merryn H Tawhai; Eric A Hoffman; Ching-Long Lin

doi:10.1007/s10439-015-1318-3

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A Numerical Study of Water Loss Rate Distributions in MDCT-Based Human Airway Models

Journal article

Peer reviewed

A Numerical Study of Water Loss Rate Distributions in MDCT-Based Human Airway Models

Dan Wu, Shinjiro Miyawaki, Merryn H Tawhai, Eric A Hoffman and Ching-Long Lin

Annals of biomedical engineering, Vol.43(11), pp.2708-2721

11/2015

DOI: 10.1007/s10439-015-1318-3

PMCID: PMC4605848

PMID: 25869455

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Abstract

Both three-dimensional (3D) and one-dimensional (1D) computational fluid dynamics methods are applied to study regional water loss in three multi-detector row computed-tomography-based human airway models at the minute ventilations of 6, 15 and 30 L/min. The overall water losses predicted by both 3D and 1D models in the entire respiratory tract agree with available experimental measurements. However, 3D and 1D models reveal different regional water loss rate distributions due to the 3D secondary flows formed at bifurcations. The secondary flows cause local skewed temperature and humidity distributions on inspiration acting to elevate the local water loss rate; and the secondary flow at the carina tends to distribute more cold air to the lower lobes. As a result, the 3D model predicts that the water loss rate first increases with increasing airway generation, and then decreases as the air approaches saturation, while the 1D model predicts a monotonic decrease of water loss rate with increasing airway generation. Moreover, the 3D (or 1D) model predicts relatively higher water loss rates in lower (or upper) lobes. The regional water loss rate can be related to the non-dimensional wall shear stress (τ (*)) by the non-dimensional mass transfer coefficient (h 0 (*) ) as [Formula: see text].

Hydrodynamics

Temperature

Humans

Male

Tomography, X-Ray Computed

Lung - diagnostic imaging

Water Loss, Insensible

Lung - physiology

Respiratory Physiological Phenomena

Young Adult

Models, Biological

Humidity

Adult

Female

Details

Title: Subtitle: A Numerical Study of Water Loss Rate Distributions in MDCT-Based Human Airway Models
Creators: Dan Wu - Department of IIHR-Hydroscience & Engineering, The University of Iowa, Iowa City, 52242, Iowa, USA
Shinjiro Miyawaki - Department of IIHR-Hydroscience & Engineering, The University of Iowa, Iowa City, 52242, Iowa, USA
Merryn H Tawhai - Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand
Eric A Hoffman - Department of Radiology, The University of Iowa, Iowa City, 52242, Iowa, USA
Ching-Long Lin - Department of IIHR-Hydroscience & Engineering, The University of Iowa, Iowa City, 52242, Iowa, USA. ching-long-lin@uiowa.edu
Resource Type: Journal article
Publication Details: Annals of biomedical engineering, Vol.43(11), pp.2708-2721
DOI: 10.1007/s10439-015-1318-3
PMID: 25869455
PMCID: PMC4605848
NLM abbreviation: Ann Biomed Eng
ISSN: 0090-6964
eISSN: 1573-9686
Publisher: United States
Grant note: U01 HL114494 / NHLBI NIH HHS U01-HL114494 / NHLBI NIH HHS P30 ES005605 / NIEHS NIH HHS R01-HL094315 / NHLBI NIH HHS R01 HL094315 / NHLBI NIH HHS R01 HL112986 / NHLBI NIH HHS S10 RR022421 / NCRR NIH HHS S10-RR022421 / NCRR NIH HHS
Language: English
Date published: 11/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
Record Identifier: 9984051564302771

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